PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11375525-1 2001 Catechol-O-methyltransferase (COMT) is involved in the metabolism of catecholamines, catechol steroids and xenobiotic catechols. Catecholamines 69-83 catechol-O-methyltransferase Rattus norvegicus 0-28 11967239-3 2002 Because catecholamines are substrates for COMT, which is expressed in GMCs, we hypothesize that catecholamines may abrogate the antimitogenic effects of 2-hydroxyestradiol on GMCs by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 8-22 catechol-O-methyltransferase Rattus norvegicus 197-201 11967239-3 2002 Because catecholamines are substrates for COMT, which is expressed in GMCs, we hypothesize that catecholamines may abrogate the antimitogenic effects of 2-hydroxyestradiol on GMCs by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 96-110 catechol-O-methyltransferase Rattus norvegicus 42-46 11967239-3 2002 Because catecholamines are substrates for COMT, which is expressed in GMCs, we hypothesize that catecholamines may abrogate the antimitogenic effects of 2-hydroxyestradiol on GMCs by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 96-110 catechol-O-methyltransferase Rattus norvegicus 197-201 11967239-12 2002 Moreover, catecholamines may abrogate the renoprotective effects of 2-hydroxyestradiol in the glomeruli by inhibiting COMT and 2-methoxyestradiol formation. Catecholamines 10-24 catechol-O-methyltransferase Rattus norvegicus 118-122 11780762-13 2001 These observations raise the possibility that some of the biological effects of tea polyphenols may be exerted by their O-methylated products or may result from their potential inhibition of the COMT-catalysed O-methylation of endogenous catecholamines and catechol oestrogens. Catecholamines 238-252 catechol-O-methyltransferase Rattus norvegicus 195-199 11375525-1 2001 Catechol-O-methyltransferase (COMT) is involved in the metabolism of catecholamines, catechol steroids and xenobiotic catechols. Catecholamines 69-83 catechol-O-methyltransferase Rattus norvegicus 30-34 11394305-7 2001 The proposed method is thought to be useful for the measurement of both S-COMT and MB-COMT activities, and would give us critical information on the role of metabolism of catecholamines in rat tissues. Catecholamines 171-185 catechol-O-methyltransferase Rattus norvegicus 86-90 11394305-7 2001 The proposed method is thought to be useful for the measurement of both S-COMT and MB-COMT activities, and would give us critical information on the role of metabolism of catecholamines in rat tissues. Catecholamines 171-185 catechol-O-methyltransferase Rattus norvegicus 74-78 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 0-28 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 30-34 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 129-133 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 129-133 2045576-3 1991 The pattern of localization suggests that COMT may function in extraneuronal inactivation of catecholamines in dental pulp. Catecholamines 93-107 catechol-O-methyltransferase Rattus norvegicus 42-46 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 0-28 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 30-34 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 88-92 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 88-92 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 catechol-O-methyltransferase Rattus norvegicus 215-243 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 catechol-O-methyltransferase Rattus norvegicus 245-249 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 catechol-O-methyltransferase Rattus norvegicus 337-341 7617303-6 1995 The results suggest that postsynaptic dendritic spines and astrocytic processes may be the sites of catecholamine inactivation by COMT in rat brain. Catecholamines 100-113 catechol-O-methyltransferase Rattus norvegicus 130-134 9262345-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that plays an important role in the inactivation of catecholamine neurotransmitters. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 0-28 9262345-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that plays an important role in the inactivation of catecholamine neurotransmitters. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 30-34 7771182-6 1995 Therefore, different from our current knowledge in rats COMT and MAOX either co-operate in catecholamine degradation or they degrade the respective catecholamines alone. Catecholamines 91-104 catechol-O-methyltransferase Rattus norvegicus 56-60 7771182-6 1995 Therefore, different from our current knowledge in rats COMT and MAOX either co-operate in catecholamine degradation or they degrade the respective catecholamines alone. Catecholamines 148-162 catechol-O-methyltransferase Rattus norvegicus 56-60 2555817-1 1989 The role of catechol-o-methyltransferase (COMT) in functional interrelationship between testosterone (T), catechol estrogens (CE) and catecholamines (CA) during cerebral sex differentiation (CSD) was investigated in experiments on Wistar rats. Catecholamines 134-148 catechol-O-methyltransferase Rattus norvegicus 12-40 2126354-6 1990 The rise of catecholamines in the hypothalamus of 10-day-old female rats induced by COMT inhibition with tropolone (0.3 mg on postnatal days 5 and 7) was unable to masculinize developing neuroendocrine regions responsible for sexual cyclicity. Catecholamines 12-26 catechol-O-methyltransferase Rattus norvegicus 84-88 2555817-1 1989 The role of catechol-o-methyltransferase (COMT) in functional interrelationship between testosterone (T), catechol estrogens (CE) and catecholamines (CA) during cerebral sex differentiation (CSD) was investigated in experiments on Wistar rats. Catecholamines 134-148 catechol-O-methyltransferase Rattus norvegicus 42-46 3683592-6 1987 The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline. Catecholamines 176-190 catechol-O-methyltransferase Rattus norvegicus 5-9 3181288-1 1988 Catechol-O-methyltransferase (COMT) has an important role in the extraneuronal inactivation of catecholamine neurotransmitters and drugs with a catechol structure. Catecholamines 95-108 catechol-O-methyltransferase Rattus norvegicus 0-28 3181288-1 1988 Catechol-O-methyltransferase (COMT) has an important role in the extraneuronal inactivation of catecholamine neurotransmitters and drugs with a catechol structure. Catecholamines 95-108 catechol-O-methyltransferase Rattus norvegicus 30-34 3683592-6 1987 The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline. Catecholamines 30-44 catechol-O-methyltransferase Rattus norvegicus 5-9 3678363-5 1987 These findings indicate that both anoxia coupled with glucose deprivation and ischemia inhibit both uptake2 and COMT activity and suggest that such inhibition may be responsible for the high concentration of catecholamines released locally following myocardial infarction. Catecholamines 208-222 catechol-O-methyltransferase Rattus norvegicus 112-116 6603348-1 1983 The effect of bilateral adrenal medullectomy on the activity of catecholamine degrading enzymes--catechol-o-methyl transferase (COMT) and monoamino oxidase (MAO)--in adrenal cortex and on the level of corticosterone in plasma was studied in the rats subjected either to a single (2.5 h) or repeated (2.5 h daily for 150 days omitting Saturdays and Sundays) immobilization stress. Catecholamines 64-77 catechol-O-methyltransferase Rattus norvegicus 88-126 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 7-20 catechol-O-methyltransferase Rattus norvegicus 63-91 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 7-20 catechol-O-methyltransferase Rattus norvegicus 184-188 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 63-91 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 184-188 6136632-7 1983 The evidence for catecholestrogen action upon COMT, an outside membrane enzyme involved in the process of catecholamine degradation, supports the idea of a catechol action for 2-OHE2. Catecholamines 106-119 catechol-O-methyltransferase Rattus norvegicus 46-50 6098975-1 1983 Since catechol estrogens are potent competitive inhibitors of catechol-O-methyl transferase (COMT), it has been suggested that they may prolong the half-life of catecholamines which in turn can cause hypertension. Catecholamines 161-175 catechol-O-methyltransferase Rattus norvegicus 62-91 6098975-1 1983 Since catechol estrogens are potent competitive inhibitors of catechol-O-methyl transferase (COMT), it has been suggested that they may prolong the half-life of catecholamines which in turn can cause hypertension. Catecholamines 161-175 catechol-O-methyltransferase Rattus norvegicus 93-97 6603348-1 1983 The effect of bilateral adrenal medullectomy on the activity of catecholamine degrading enzymes--catechol-o-methyl transferase (COMT) and monoamino oxidase (MAO)--in adrenal cortex and on the level of corticosterone in plasma was studied in the rats subjected either to a single (2.5 h) or repeated (2.5 h daily for 150 days omitting Saturdays and Sundays) immobilization stress. Catecholamines 64-77 catechol-O-methyltransferase Rattus norvegicus 128-132 7160182-1 1982 Catechol-O-methyltransferase (COMT) is a key enzyme in the metabolism of catecholamines. Catecholamines 73-87 catechol-O-methyltransferase Rattus norvegicus 0-28 7160182-1 1982 Catechol-O-methyltransferase (COMT) is a key enzyme in the metabolism of catecholamines. Catecholamines 73-87 catechol-O-methyltransferase Rattus norvegicus 30-34 1079183-1 1975 The activity of catecholamine degrading enzymes (catechol-O-methyltransferase--COMT and monoamine oxidase--MAO) in separated adrenal cortex and medulla was measured in rats stressed by a singel or repeated immobilization. Catecholamines 16-29 catechol-O-methyltransferase Rattus norvegicus 79-83 7366740-3 1980 Its essential features are: a saturable uptake process (uptake 2), a saturable, intracompartmental enzyme (COMT), the ability of the catecholamine to penetrate the membrane of the model compartment by a diffusional flux obeying first-order kinetics, and the ability of the metabolite to leave the compartment by an efflux obeying first-order kinetics. Catecholamines 133-146 catechol-O-methyltransferase Rattus norvegicus 107-111 7121616-4 1982 This implies an insignificant role for plasma membrane COMT although reported altered kinetic behaviour could elevate microsomal COMT to a supporting role in the regulation of catecholamine concentration in the circulation. Catecholamines 176-189 catechol-O-methyltransferase Rattus norvegicus 129-133 538080-3 1979 In order to learn whether p-hydroxyamphetamine can be further metabolized to a catecholamine, a sensitive radioenzymatic assay was developed which couples the formation of the "catecholamphetamine" to rapid O-methylation by catechol-O-methyltransferase in the presence of [3H]-methyl-S-adenosylmethionine. Catecholamines 79-92 catechol-O-methyltransferase Rattus norvegicus 224-252 952582-7 1976 The results of these studies indicate that ketamine prevented catecholamines from reaching the intracellular site of COMT. Catecholamines 62-76 catechol-O-methyltransferase Rattus norvegicus 117-121 1079183-6 1975 It was concluded that the findings of changed activity of catecholamine degrading enzymes, namely a decreased activity of COMT in both adrenal cortex and medulla in repeatedly stressed rats, might show a possible participation of these enzymes in increased catecholamine content in adrenals of repeatedly stressed animals. Catecholamines 58-71 catechol-O-methyltransferase Rattus norvegicus 122-126 1079183-6 1975 It was concluded that the findings of changed activity of catecholamine degrading enzymes, namely a decreased activity of COMT in both adrenal cortex and medulla in repeatedly stressed rats, might show a possible participation of these enzymes in increased catecholamine content in adrenals of repeatedly stressed animals. Catecholamines 257-270 catechol-O-methyltransferase Rattus norvegicus 122-126 32750363-9 2020 In addition, these effects of PIO were associated with up-regulating COMT expression with a subsequent reduction in plasma catecholamines levels. Catecholamines 123-137 catechol-O-methyltransferase Rattus norvegicus 69-73 29935309-1 2018 Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Catecholamines 215-229 catechol-O-methyltransferase Rattus norvegicus 152-180 31491076-2 2019 Catechol-O-methyltransferase (COMT) is involved in the inactivation of the catecholamine neurotransmitters, and it is particularly important for the regulation of dopamine. Catecholamines 75-88 catechol-O-methyltransferase Rattus norvegicus 0-28 31491076-2 2019 Catechol-O-methyltransferase (COMT) is involved in the inactivation of the catecholamine neurotransmitters, and it is particularly important for the regulation of dopamine. Catecholamines 75-88 catechol-O-methyltransferase Rattus norvegicus 30-34 29935309-1 2018 Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Catecholamines 215-229 catechol-O-methyltransferase Rattus norvegicus 182-186 29310047-1 2018 Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. Catecholamines 150-164 catechol-O-methyltransferase Rattus norvegicus 21-50 29310047-1 2018 Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. Catecholamines 150-164 catechol-O-methyltransferase Rattus norvegicus 52-56 28862601-1 2017 Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism (monoaminbe oxidases A and B (MAO A and MAO B) and catechol-O-methyl transferase (COMT)) and renalase has been carried out in tissues of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Catecholamines 64-77 catechol-O-methyltransferase Rattus norvegicus 140-169 28862601-2 2017 Among investigated tissues the highest level of mRNA of genes encoding key enzymes of catecholamine catabolism (MAO A, MAO B, COMT) was found in the heart of WKY rats. Catecholamines 86-99 catechol-O-methyltransferase Rattus norvegicus 126-130 28066248-2 2016 One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 195-209 catechol-O-methyltransferase Rattus norvegicus 68-96 28066248-2 2016 One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 195-209 catechol-O-methyltransferase Rattus norvegicus 98-102 28066248-13 2016 Importantly, this sensitive assay was able to detect the presence of COMT activity in extracellular vesicles secreted by hepatocytes supporting a potential role of these vesicles in catecholamines and catecholestrogens metabolisms. Catecholamines 182-196 catechol-O-methyltransferase Rattus norvegicus 69-73 23613951-1 2013 The catechol-O-methyltransferase (COMT) enzyme metabolises catecholamines. Catecholamines 59-73 catechol-O-methyltransferase Rattus norvegicus 4-32 26187567-3 2015 A recent in vitro study further demonstrates that increased NF-kappaB activity in astrocytes decreases transcription of catechol-o-methyltransferase (COMT), an enzyme that inactivates catecholamines that cause pain. Catecholamines 184-198 catechol-O-methyltransferase Rattus norvegicus 120-148 26187567-3 2015 A recent in vitro study further demonstrates that increased NF-kappaB activity in astrocytes decreases transcription of catechol-o-methyltransferase (COMT), an enzyme that inactivates catecholamines that cause pain. Catecholamines 184-198 catechol-O-methyltransferase Rattus norvegicus 150-154 25560240-1 2014 Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Catecholamines 62-75 catechol-O-methyltransferase Rattus norvegicus 0-28 25560240-1 2014 Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Catecholamines 62-75 catechol-O-methyltransferase Rattus norvegicus 30-34 26919286-2 2016 Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine. Catecholamines 42-55 catechol-O-methyltransferase Rattus norvegicus 0-29 26919286-2 2016 Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine. Catecholamines 42-55 catechol-O-methyltransferase Rattus norvegicus 31-35 23613951-1 2013 The catechol-O-methyltransferase (COMT) enzyme metabolises catecholamines. Catecholamines 59-73 catechol-O-methyltransferase Rattus norvegicus 34-38 18981694-1 2008 Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Rattus norvegicus 162-190 22815336-1 2012 Catechol-O-methyltransferase (COMT) catabolises the catecholamine neurotransmitters and influences cognitive function. Catecholamines 52-65 catechol-O-methyltransferase Rattus norvegicus 0-28 22815336-1 2012 Catechol-O-methyltransferase (COMT) catabolises the catecholamine neurotransmitters and influences cognitive function. Catecholamines 52-65 catechol-O-methyltransferase Rattus norvegicus 30-34 19966533-7 2009 Among them, we focused on catechol-O-methyltransferase (COMT) because this enzyme inactivates catecholamines, possibly affecting blood pressure. Catecholamines 94-108 catechol-O-methyltransferase Rattus norvegicus 26-54 19966533-7 2009 Among them, we focused on catechol-O-methyltransferase (COMT) because this enzyme inactivates catecholamines, possibly affecting blood pressure. Catecholamines 94-108 catechol-O-methyltransferase Rattus norvegicus 56-60 20616572-1 2010 BACKGROUND/AIMS: The plasma concentration of catecholamines and their metabolites generated by catechol-O-methyl transferase (COMT) were measured and their correlation with the progress of renal dysfunction was investigated in two distinctive animal models: a 5/6 nephrectomized Sprague-Dawley rat model and a 1/2 nephrectomized diabetic fatty Zucker rat model. Catecholamines 45-59 catechol-O-methyltransferase Rattus norvegicus 126-130 18981694-1 2008 Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Rattus norvegicus 192-196 18981694-3 2008 Using the developed method, we have found that inactivation of catecholamines by COMT is attenuated in hypertensive rats compared to normotensive rats. Catecholamines 63-77 catechol-O-methyltransferase Rattus norvegicus 81-85 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 89-103 catechol-O-methyltransferase Rattus norvegicus 14-42 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 89-103 catechol-O-methyltransferase Rattus norvegicus 44-48 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 105-108 catechol-O-methyltransferase Rattus norvegicus 14-42 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 105-108 catechol-O-methyltransferase Rattus norvegicus 44-48 17587758-1 2007 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 66-80 catechol-O-methyltransferase Rattus norvegicus 0-28 17587758-1 2007 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 66-80 catechol-O-methyltransferase Rattus norvegicus 30-34 14714585-1 2003 We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Catecholamines 48-62 catechol-O-methyltransferase Rattus norvegicus 66-94 14714585-1 2003 We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Catecholamines 48-62 catechol-O-methyltransferase Rattus norvegicus 96-100 17084978-5 2007 To characterize the means whereby elevated catecholamine levels, resulting from reduced COMT activity, modulate heightened pain sensitivity, we administered a COMT inhibitor to rats and measured behavioral responsiveness to mechanical and thermal stimuli. Catecholamines 43-56 catechol-O-methyltransferase Rattus norvegicus 88-92 17084978-5 2007 To characterize the means whereby elevated catecholamine levels, resulting from reduced COMT activity, modulate heightened pain sensitivity, we administered a COMT inhibitor to rats and measured behavioral responsiveness to mechanical and thermal stimuli. Catecholamines 43-56 catechol-O-methyltransferase Rattus norvegicus 159-163 16462018-3 2006 We have reported that the inactivation of CAs by catechol-O-methyltransferase (COMT) in the liver is important in high blood pressure in spontaneously hypertensive rats (SHR). Catecholamines 42-45 catechol-O-methyltransferase Rattus norvegicus 49-77 16462018-3 2006 We have reported that the inactivation of CAs by catechol-O-methyltransferase (COMT) in the liver is important in high blood pressure in spontaneously hypertensive rats (SHR). Catecholamines 42-45 catechol-O-methyltransferase Rattus norvegicus 79-83