PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25193238-5 2014 Here we report that systematic administration of BBG diminishes spatial memory impairment and cognitive deficits in a mouse AD model produced by injecting soluble Abeta peptide into the hippocampal CA1 region. coomassie Brilliant Blue 49-52 amyloid beta (A4) precursor protein Mus musculus 163-168 25193238-6 2014 In addition, we show that Abeta-induced loss of filopodia and spine density in cultured hippocampal neurons was prevented by administration of BBG. coomassie Brilliant Blue 143-146 amyloid beta (A4) precursor protein Mus musculus 26-31 25193238-7 2014 We conclude that BBG prevents the learning and memory impairment and cognitive deficits induced by the toxicity of soluble Abeta, and improves the development of dendritic spines in hippocampal neurons in an AD model mouse. coomassie Brilliant Blue 17-20 amyloid beta (A4) precursor protein Mus musculus 123-128 27258855-4 2016 We found that the BBG-induced decrease in Abeta binding resulted in a significant decrease in its neurotoxicity. coomassie Brilliant Blue 18-21 amyloid beta (A4) precursor protein Mus musculus 42-47