PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34693115-4	2021	Tan IIA may be the main active component of CDDP in the treatment of high-altitude heart disease via HIF-1/PI3K/Akt pathways.	cddp	44-48	AKT serine/threonine kinase 1	Homo sapiens	112-115	
28537902-3	2017	Increasing concentrations of tunicamycin and CDDP activated ERS in SKOV3 cells, reduced cell viability and proliferation, increased apoptosis and autophagy, enhanced expression of ERS-related proteins, and inhibited expression of PI3K/AKT/mTOR pathway-related proteins.	cddp	45-49	AKT serine/threonine kinase 1	Homo sapiens	235-238	
31255669-6	2019	Results documented that neferine/isoliensinine with CDDP augmented "intracellular uptake of cisplatin" consequently apoptosis in HCT-15 cells exemplified by "apoptotic morphological changes", "S phase cell cycle arrest", "ROS mediated oxidative stress" with the concomitant escalation in intracellular calcium & dissipation of MMP and activation of MAPK/PI3K/AKT pathway".	cddp	52-56	AKT serine/threonine kinase 1	Homo sapiens	363-366	
29964327-7	2019	We also found that the combination of CDDP and DAPT exhibit additive suppression on phosphorylated AKT and ERK, contributing to the anti-cancer effects.	cddp	38-42	AKT serine/threonine kinase 1	Homo sapiens	99-102	
26088228-0	2015	Re: The PDGFRbeta-AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors.	cddp	45-49	AKT serine/threonine kinase 1	Homo sapiens	18-21	
25154814-6	2015	Moreover, whether Akt regulates PPM1D in the context of CDDP resistance has not been studied.	cddp	56-60	AKT serine/threonine kinase 1	Homo sapiens	18-21	
25154814-8	2015	In conclusion, we have established that PPM1D plays an important role in promoting CDDP resistance and as a novel downstream target of Akt, PPM1D mediates its action in conferring CDDP resistance in gynecological cancer cells.	cddp	83-87	AKT serine/threonine kinase 1	Homo sapiens	135-138	
25154814-8	2015	In conclusion, we have established that PPM1D plays an important role in promoting CDDP resistance and as a novel downstream target of Akt, PPM1D mediates its action in conferring CDDP resistance in gynecological cancer cells.	cddp	180-184	AKT serine/threonine kinase 1	Homo sapiens	135-138