PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31255669-6 2019 Results documented that neferine/isoliensinine with CDDP augmented "intracellular uptake of cisplatin" consequently apoptosis in HCT-15 cells exemplified by "apoptotic morphological changes", "S phase cell cycle arrest", "ROS mediated oxidative stress" with the concomitant escalation in intracellular calcium & dissipation of MMP and activation of MAPK/PI3K/AKT pathway". cddp 52-56 AKT serine/threonine kinase 1 Homo sapiens 363-366 34693115-4 2021 Tan IIA may be the main active component of CDDP in the treatment of high-altitude heart disease via HIF-1/PI3K/Akt pathways. cddp 44-48 AKT serine/threonine kinase 1 Homo sapiens 112-115 28537902-3 2017 Increasing concentrations of tunicamycin and CDDP activated ERS in SKOV3 cells, reduced cell viability and proliferation, increased apoptosis and autophagy, enhanced expression of ERS-related proteins, and inhibited expression of PI3K/AKT/mTOR pathway-related proteins. cddp 45-49 AKT serine/threonine kinase 1 Homo sapiens 235-238 29964327-7 2019 We also found that the combination of CDDP and DAPT exhibit additive suppression on phosphorylated AKT and ERK, contributing to the anti-cancer effects. cddp 38-42 AKT serine/threonine kinase 1 Homo sapiens 99-102 26088228-0 2015 Re: The PDGFRbeta-AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors. cddp 45-49 AKT serine/threonine kinase 1 Homo sapiens 18-21 25154814-6 2015 Moreover, whether Akt regulates PPM1D in the context of CDDP resistance has not been studied. cddp 56-60 AKT serine/threonine kinase 1 Homo sapiens 18-21 25154814-8 2015 In conclusion, we have established that PPM1D plays an important role in promoting CDDP resistance and as a novel downstream target of Akt, PPM1D mediates its action in conferring CDDP resistance in gynecological cancer cells. cddp 83-87 AKT serine/threonine kinase 1 Homo sapiens 135-138 25154814-8 2015 In conclusion, we have established that PPM1D plays an important role in promoting CDDP resistance and as a novel downstream target of Akt, PPM1D mediates its action in conferring CDDP resistance in gynecological cancer cells. cddp 180-184 AKT serine/threonine kinase 1 Homo sapiens 135-138