PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25693518-7	2015	Host cell reactivation assay revealed that MGMT protected NPC cells from CDDP-induced DNA damage by enhancing DNA repair capacity.	cddp	73-77	O-6-methylguanine-DNA methyltransferase	Homo sapiens	43-47	
25693518-5	2015	In this study, we showed that MGMT-proficient cells were highly resistant to the cytotoxic effects of CDDP as compared to MGMT-deficient cells.	cddp	102-106	O-6-methylguanine-DNA methyltransferase	Homo sapiens	30-34	
25693518-6	2015	Further studies showed that the platinum level of DNA after CDDP exposure was significantly lower in MGMT-proficient cells than in MGMT-deficient cells.	cddp	60-64	O-6-methylguanine-DNA methyltransferase	Homo sapiens	101-105	
25693518-6	2015	Further studies showed that the platinum level of DNA after CDDP exposure was significantly lower in MGMT-proficient cells than in MGMT-deficient cells.	cddp	60-64	O-6-methylguanine-DNA methyltransferase	Homo sapiens	131-135	
25693518-8	2015	Importantly, we demonstrated for the first time that MGMT protein directly bound to CDDP-induced DNA damages.	cddp	84-88	O-6-methylguanine-DNA methyltransferase	Homo sapiens	53-57	
25693518-9	2015	Subsequently, CDDP-bound MGMT protein became ubiquitinated and was degraded through ubiquitin-mediated proteasome system.	cddp	14-18	O-6-methylguanine-DNA methyltransferase	Homo sapiens	25-29	
25693518-11	2015	NPC patients who received CDDP-based concurrent chemoradiotherapy (CCRT), with high MGMT expression level, exhibited shorter progression-free survival (PFS; p = 0.022) and overall survival (OS; p = 0.015), than patients with low MGMT expression level.	cddp	26-30	O-6-methylguanine-DNA methyltransferase	Homo sapiens	84-88	
25693518-11	2015	NPC patients who received CDDP-based concurrent chemoradiotherapy (CCRT), with high MGMT expression level, exhibited shorter progression-free survival (PFS; p = 0.022) and overall survival (OS; p = 0.015), than patients with low MGMT expression level.	cddp	26-30	O-6-methylguanine-DNA methyltransferase	Homo sapiens	229-233	
25693518-13	2015	Our findings suggest that MGMT protein is important to determine the efficacy of CDDP in NPC.	cddp	81-85	O-6-methylguanine-DNA methyltransferase	Homo sapiens	26-30	
29601666-4	2018	Our results demonstrated that Trps1 and MGMT expression both increased in drug-resistant lung cancer cell line (H446/CDDP).	cddp	117-121	O-6-methylguanine-DNA methyltransferase	Homo sapiens	40-44	
29601666-6	2018	Ectopic expression of MGMT had no effect on Trps1 expression, but enhanced the IC50 values of H446 cells or rescued the IC50 values of Trps1-silenced H446/CDDP cells in treatment of multidrug.	cddp	155-159	O-6-methylguanine-DNA methyltransferase	Homo sapiens	22-26	
16043385-3	2005	In the present study, the association between MGMT expression and the cellular sensitivity to the platinum agent, CDDP was examined in four human oral cancer cell lines.	cddp	114-118	O-6-methylguanine-DNA methyltransferase	Homo sapiens	46-50	
16043385-4	2005	CDDP depleted MGMT protein and mRNA levels in all four cell lines.	cddp	0-4	O-6-methylguanine-DNA methyltransferase	Homo sapiens	14-18	
16043385-5	2005	Two cell lines with low MGMT expression were sensitive to an alkylating agent, N-methyl-N"-nitro-N-nitrosoguanidine and CDDP, whereas two other cell lines with high MGMT expression were resistant to both agents.	cddp	120-124	O-6-methylguanine-DNA methyltransferase	Homo sapiens	24-28	
16043385-6	2005	Furthermore, the addition of the MGMT inhibitor, O6-benzylguanine (O6-BG), invariably enhanced CDDP sensitivity.	cddp	95-99	O-6-methylguanine-DNA methyltransferase	Homo sapiens	33-37	
16043385-7	2005	CDDP depleted MGMT expression, and CDDP sensitivity was enhanced by O6-BG.	cddp	0-4	O-6-methylguanine-DNA methyltransferase	Homo sapiens	14-18	
16043385-8	2005	These results provide valuable information about the relationship between MGMT expression and CDDP sensitivity in oral cancer chemotherapy.	cddp	94-98	O-6-methylguanine-DNA methyltransferase	Homo sapiens	74-78