PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15067056-9 2004 Based on these data, we propose that the decision as to whether TCR engagement will lead to productive activation or tolerance is dictated by a rapamycin -inhibitable pathway, independent of the G(1)-->S phase cell cycle progression. Sirolimus 144-153 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 64-67 15944259-5 2005 In the present study, we showed that TCR engagement does not influence hypoxia-dependent stabilization but stimulates protein synthesis of HIF-1alpha, most possibly via PI3K/mammalian target of rapamycin system, and that expression of HIF-1alpha and its target genes is blocked by treatment with rapamycin. Sirolimus 194-203 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 37-40 15162441-5 2004 While blockade of TCR signaling pathways with inhibitors of the phosphatidylinositol 3-kinase pathway caused a partial pre-integration block, another inhibitor, rapamycin, completely suppressed the infection. Sirolimus 161-170 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 18-21 8660826-5 1996 Prevention of cell death correlated with delayed entry into S phase from G1 following TCR religation in the rapamycin-treated cultures. Sirolimus 108-117 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 86-89