PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32032574-5	2020	Treatment of mice at P7 with rapamycin or 3-methyladenine (activator and inhibitor of autophagy, respectively) for 7 days led to the significant elevations of hearing threshold across frequencies from P15 to P30.	Sirolimus	29-38	high mobility group box 1	Mus musculus	208-211	
32072192-9	2020	Mechanistic studies revealed that HMGB1 activates receptor for AGE (RAGE) and toll-like receptor (TLR)4 to enhance phosphatidylinositol 3-kinase (PI3K)-Akt-mechanistic target of rapamycin (mTOR) signalling, thereby impairing Treg stability and functionality.	Sirolimus	178-187	high mobility group box 1	Mus musculus	34-39	
31924219-15	2020	When the autophagy inducer, rapamycin, is used to facilitate the mitophagy flux, this treatment results in attenuated NF-kappaB activation and reduced PIC release in exogenous disulfide HMGB1 (ds-HMGB1)-stimulated microglia.	Sirolimus	28-37	high mobility group box 1	Mus musculus	186-191	
31924219-15	2020	When the autophagy inducer, rapamycin, is used to facilitate the mitophagy flux, this treatment results in attenuated NF-kappaB activation and reduced PIC release in exogenous disulfide HMGB1 (ds-HMGB1)-stimulated microglia.	Sirolimus	28-37	high mobility group box 1	Mus musculus	196-201	
21625955-5	2011	Rapamycin-treated mice showed lower birth weight, lower body weight, and liver growth retardation in a pattern similar to that observed in the hypoxic mice at P30.	Sirolimus	0-9	high mobility group box 1	Mus musculus	159-162