PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31689244-6 2020 Furthermore, we found that sirolimus activated ALK2-mediated Smad1/5/8 signaling in primary ECs-including in HHT patient blood outgrowth ECs-and partially rescued Smad1/5/8 activity in vivo in BMP9/10ib mouse ECs. Sirolimus 27-36 activin A receptor type 1 Homo sapiens 47-51 32448372-0 2020 Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1. Sirolimus 26-35 activin A receptor type 1 Homo sapiens 147-152