PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15897901-5 2005 Comparison of the p53-induced patterns of eIF4GI and 4E-BP1 dephosphorylation and cleavage with those caused by the mTOR inhibitor rapamycin indicates that p53 activation and rapamycin have distinct but additive effects. Sirolimus 131-140 transformation related protein 53, pseudogene Mus musculus 18-21 15897901-5 2005 Comparison of the p53-induced patterns of eIF4GI and 4E-BP1 dephosphorylation and cleavage with those caused by the mTOR inhibitor rapamycin indicates that p53 activation and rapamycin have distinct but additive effects. Sirolimus 131-140 transformation related protein 53, pseudogene Mus musculus 156-159 10771484-5 2000 Immuno- precipitated FKBP12-rapamycin-associated protein was stimulated by ultraviolet-irradiated DNA to phosphorylate p53 in vitro, and in vivo rapamycin reduced ultraviolet induction of p53 by 20%. Sirolimus 28-37 transformation related protein 53, pseudogene Mus musculus 119-122 11309295-11 2001 The response to rapamycin was next examined in wild-type or murine embryo fibroblasts nullizygous for p53or p21(CIP1). Sirolimus 16-25 transformation related protein 53, pseudogene Mus musculus 102-105 11309295-15 2001 Under serum-containing conditions, rapamycin inhibited incorporation of BrdUrd significantly more in wild-type murine embryo fibroblasts (MEFs) than in those lacking p53 or p21(CIP1). Sirolimus 35-44 transformation related protein 53, pseudogene Mus musculus 166-169 10771484-5 2000 Immuno- precipitated FKBP12-rapamycin-associated protein was stimulated by ultraviolet-irradiated DNA to phosphorylate p53 in vitro, and in vivo rapamycin reduced ultraviolet induction of p53 by 20%. Sirolimus 28-37 transformation related protein 53, pseudogene Mus musculus 188-191 34853727-5 2021 Mechanistically, HFD- or PA-initiated lipotoxicity suppressed the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR)/murine double minute 2 homolog (MDM2) signaling cascade to activate p53 and enhance the transcriptional activity of LincRNA-p21. Sirolimus 148-157 transformation related protein 53, pseudogene Mus musculus 233-236 32738450-13 2021 The mTOR inhibitor rapamycin significantly reduced hepatocarcinogenesis triggered by Tsc1 loss and p53 haploinsufficiency in vivo, as well as the biomarker Abcc4. Sirolimus 19-28 transformation related protein 53, pseudogene Mus musculus 99-102 33508145-13 2021 By inhibiting p53 alone or both mTORC1 and p53 with rapamycin and a p53 inhibitor, we elucidated that p53 acts downstream of mTORC1 and that mTORC1 thereby promotes odontoblast mineralization. Sirolimus 52-61 transformation related protein 53, pseudogene Mus musculus 43-46 33508145-13 2021 By inhibiting p53 alone or both mTORC1 and p53 with rapamycin and a p53 inhibitor, we elucidated that p53 acts downstream of mTORC1 and that mTORC1 thereby promotes odontoblast mineralization. Sirolimus 52-61 transformation related protein 53, pseudogene Mus musculus 43-46 33508145-13 2021 By inhibiting p53 alone or both mTORC1 and p53 with rapamycin and a p53 inhibitor, we elucidated that p53 acts downstream of mTORC1 and that mTORC1 thereby promotes odontoblast mineralization. Sirolimus 52-61 transformation related protein 53, pseudogene Mus musculus 43-46 35187108-8 2021 Combined with intraperitoneal injection of rapamycin, the effect of autophagy on AOPP-induced p53 SUMOylation was also confirmed in vivo. Sirolimus 43-52 transformation related protein 53, pseudogene Mus musculus 94-97 33469286-12 2021 In addition, rapamycin liposomes and 5-FU can synergistically improve the efficacy of colorectal cancer via the Akt/mTOR and P53 pathways. Sirolimus 13-22 transformation related protein 53, pseudogene Mus musculus 125-128 23454868-3 2013 Here we report that downregulation of mTOR by radiation is Fbxw7-dependent, and short-term mTOR inhibition by rapamycin after exposure to radiation significantly postpones tumor development in Fbxw7/p53 double heterozygous (Fbxw7+/-p53+/-) mice but not in p53 single heterozygous (p53+/-) mice. Sirolimus 110-119 transformation related protein 53, pseudogene Mus musculus 232-235 28713484-12 2017 Western blot analysis showed that rapamycin could upregulate ULK1, ATG13 and downregulate mTORC1 and p53 protein expression. Sirolimus 34-43 transformation related protein 53, pseudogene Mus musculus 101-104 25438952-0 2015 Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis. Sirolimus 0-9 transformation related protein 53, pseudogene Mus musculus 149-152 25438952-9 2015 RESULTS: Rapamycin administration after TBI was associated with an increased number of neurons, decreased apoptosis index, and improved neurobehavioral function, which was potentially mediated by inactivation of the mTOR-p53-Bax axis. Sirolimus 9-18 transformation related protein 53, pseudogene Mus musculus 221-224 23454868-3 2013 Here we report that downregulation of mTOR by radiation is Fbxw7-dependent, and short-term mTOR inhibition by rapamycin after exposure to radiation significantly postpones tumor development in Fbxw7/p53 double heterozygous (Fbxw7+/-p53+/-) mice but not in p53 single heterozygous (p53+/-) mice. Sirolimus 110-119 transformation related protein 53, pseudogene Mus musculus 199-202 23454868-3 2013 Here we report that downregulation of mTOR by radiation is Fbxw7-dependent, and short-term mTOR inhibition by rapamycin after exposure to radiation significantly postpones tumor development in Fbxw7/p53 double heterozygous (Fbxw7+/-p53+/-) mice but not in p53 single heterozygous (p53+/-) mice. Sirolimus 110-119 transformation related protein 53, pseudogene Mus musculus 232-235 23454868-3 2013 Here we report that downregulation of mTOR by radiation is Fbxw7-dependent, and short-term mTOR inhibition by rapamycin after exposure to radiation significantly postpones tumor development in Fbxw7/p53 double heterozygous (Fbxw7+/-p53+/-) mice but not in p53 single heterozygous (p53+/-) mice. Sirolimus 110-119 transformation related protein 53, pseudogene Mus musculus 232-235 29257864-7 2018 Moreover, rapamycin pretreatment protected against colistin-induced mitochondrial dysfunction, caspase activation, and subsequent apoptosis by up-regulating autophagy and activating the Akt/CREB, NGF, and Nrf2 pathways, while inhibiting p53 signaling. Sirolimus 10-19 transformation related protein 53, pseudogene Mus musculus 237-240 23123616-4 2012 We hypothesize that rapamycin can delay cancer in heterozygous p53+/- mice. Sirolimus 20-29 transformation related protein 53, pseudogene Mus musculus 63-66 23233735-6 2013 Correspondingly, a 1.5- to five-fold reduction (P = 0.07) or a two- to three-fold increase (P < 0.001) was found in cell clusters overexpressing mutant p53 in chronically UV-exposed skin of mice that had been fed rapamycin or cyclosporine, respectively. Sirolimus 216-225 transformation related protein 53, pseudogene Mus musculus 155-158 23123616-5 2012 Here we show that rapamycin (given in a drinking water) extended the mean lifespan of p53+/- mice by 10% and when treatment started early in life (at the age less than 5 months) by 28%. Sirolimus 18-27 transformation related protein 53, pseudogene Mus musculus 86-89 23128359-0 2012 Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency. Sirolimus 0-9 transformation related protein 53, pseudogene Mus musculus 80-83 22559167-12 2012 The alteration of the mRNA expression of cell cycle inhibitors p53, p27, p21 and apoptosis associated genes Bcl-2, Bax were also involved in the synergistic antitumor effects of rapamycin and bortezomib. Sirolimus 178-187 transformation related protein 53, pseudogene Mus musculus 63-66 22161643-0 2012 Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset. Sirolimus 0-9 transformation related protein 53, pseudogene Mus musculus 41-44 22161643-12 2012 Thus, we conclude that rapamycin reduces the formation of mutant-p53-expressing cell clusters without affecting tumor onset, suggesting that tumors grow out of a minor subset of cell clusters, the formation of which is not affected by rapamycin. Sirolimus 23-32 transformation related protein 53, pseudogene Mus musculus 65-68 22559167-13 2012 P53 inhibitor PFT-alpha significantly attenuate the effect of rapamycin and bortezomib on cell apoptosis, which indicated that the pro-apoptotic effect of rapamycin and bortezomib may be p53-dependent. Sirolimus 62-71 transformation related protein 53, pseudogene Mus musculus 0-3 22559167-13 2012 P53 inhibitor PFT-alpha significantly attenuate the effect of rapamycin and bortezomib on cell apoptosis, which indicated that the pro-apoptotic effect of rapamycin and bortezomib may be p53-dependent. Sirolimus 62-71 transformation related protein 53, pseudogene Mus musculus 187-190 22559167-13 2012 P53 inhibitor PFT-alpha significantly attenuate the effect of rapamycin and bortezomib on cell apoptosis, which indicated that the pro-apoptotic effect of rapamycin and bortezomib may be p53-dependent. Sirolimus 155-164 transformation related protein 53, pseudogene Mus musculus 0-3 22559167-13 2012 P53 inhibitor PFT-alpha significantly attenuate the effect of rapamycin and bortezomib on cell apoptosis, which indicated that the pro-apoptotic effect of rapamycin and bortezomib may be p53-dependent. Sirolimus 155-164 transformation related protein 53, pseudogene Mus musculus 187-190 19435901-0 2009 Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Sirolimus 0-9 transformation related protein 53, pseudogene Mus musculus 78-81