PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28400999-7	2017	Rapamycin and its analogues (rapalogues) bind to the intercellular receptor FKBP12, and then predominantly inhibit mTORC1 signaling via an allosteric mechanism.	Sirolimus	0-9	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	76-82	
26314990-4	2016	Computational modeling confirmed that diffusion and binding constants of Corolimus and Sirolimus are identical and explained that the sustained retention of Corolimus was facilitated by binding to high affinity intracellular receptors (FKBP12).	Sirolimus	87-96	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	236-242	
19351700-4	2009	The imaging utility of BRET3 at the single-cell level is demonstrated using an intramolecular sensor incorporating two mammalian target of rapamycin pathway proteins (FKBP12 and FRB) that dimerize only in the presence of rapamycin.	Sirolimus	139-148	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	167-173	
23305836-4	2013	Although FKBP12 was first identified as the principal intracellular target for the immunosuppressive drugs, FK506 and rapamycin, new insights into the role of FKBPs have since emerged.	Sirolimus	118-127	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	9-15	
9742506-1	1998	BACKGROUND: The 12 kD FK506 binding protein FKBP12 is a cytosolic receptor for the immunosuppressant drugs FK506 and rapamycin.	Sirolimus	117-126	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	44-50	
17950843-7	2008	Under these conditions FK506, which displaces FKBP12 (to inhibit calcineurin) and rapamycin, which displaces FKBP12 (to inhibit mTOR), each increased the [Ca(2+)](c) rise evoked by caffeine.	Sirolimus	82-91	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	109-115	
10361256-2	1999	The mechanism of this inhibition is investigated using FK506, which competes with rapamycin for binding to their common target FK506-binding protein (FKBP)12.	Sirolimus	82-91	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	150-157	
7809080-3	1994	Using a two-hybrid system we isolated mammalian clones that interact with the human FK506/rapamycin-binding protein (FKBP12) in the presence of rapamycin.	Sirolimus	90-99	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	117-123	
9434772-4	1997	Protein kinase activity directed towards mTOR was tightly associated with mTOR immunoprecipitates and this kinase activity was inhibited by FKBP12-rapamycin indicating it was due to an autokinase activity present in mTOR.	Sirolimus	147-156	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	140-146	
8413204-2	1993	In Saccharomyces cerevisiae, rapamycin sensitivity is mediated by a specific cytoplasmic receptor which is a homolog of human FKBP12 (hFKBP12).	Sirolimus	29-38	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	126-132	
8413204-2	1993	In Saccharomyces cerevisiae, rapamycin sensitivity is mediated by a specific cytoplasmic receptor which is a homolog of human FKBP12 (hFKBP12).	Sirolimus	29-38	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	134-141	
8413204-3	1993	Deletion of the gene for yeast FKBP12 (RBP1) results in recessive drug resistance, and expression of hFKBP12 restores rapamycin sensitivity.	Sirolimus	118-127	FKBP prolyl isomerase 1A pseudogene 3	Homo sapiens	101-108