PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25428129-7	2015	Inhibition of mTOR with rapamycin partially suppressed the phosphorylation of PERK and eIF2a and the induction of CHOP and GRP78 induction during tunicamycin treatment.	Sirolimus	24-33	DNA damage inducible transcript 3	Homo sapiens	114-118	
30746902-5	2019	Gly-HDL-induced apoptosis, PERK phosphorylation and CHOP up-regulation were suppressed by rapamycin (an autophagy inducer), whereas aggravated by 3-methyladenine (an autophagy inhibitor) and beclin-1 siRNA.	Sirolimus	90-99	DNA damage inducible transcript 3	Homo sapiens	52-56	
29554648-12	2018	Increased phospho-AMPKalpha, CHOP and Grp78 as well as cellular apoptosis were prevented by mTOR inhibitor rapamycin in HG-treated podocytes.	Sirolimus	107-116	DNA damage inducible transcript 3	Homo sapiens	29-33	
30863363-10	2019	Both palmitate and brefeldin induced PERK, CHOP and BiP gene expression, which was partially, but significantly prevented by rapamycin.	Sirolimus	125-134	DNA damage inducible transcript 3	Homo sapiens	43-47	
30863363-12	2019	Compared to untreated T2D cells, rapamycin-exposed diabetic islets showed improved insulin secretion, reduced proportion of beta cells showing signs of apoptosis and better preserved insulin granules, mitochondria and ER ultrastructure; this was associated with significant reduction of PERK, CHOP and BiP gene expression.	Sirolimus	33-42	DNA damage inducible transcript 3	Homo sapiens	293-297	
29314656-8	2018	Moreover, rapamycin significantly mitigated MI/R-induced endoplasmic reticulum stress and mitochondrial impairment demonstrated by reduced Caspase-12 activity, inhibited CHOP activation, decreased cytoplasmic Cyto-C release and preserved intact mitochondria.	Sirolimus	10-19	DNA damage inducible transcript 3	Homo sapiens	170-174	
25653476-6	2015	Rapamycin attenuated PA-induced PERK and IRE1-associated UPR pathways, evidenced by decreased protein levels of eIF2alpha phosphorylation, ATF4, CHOP, and JNK phosphorylation.	Sirolimus	0-9	DNA damage inducible transcript 3	Homo sapiens	145-149	
19420259-5	2009	In Tsc2-deficient neurons, the expression of stress markers such as CHOP and HO-1 is increased, and this increase is completely reversed by the mTOR inhibitor rapamycin both in vitro and in vivo.	Sirolimus	159-168	DNA damage inducible transcript 3	Homo sapiens	68-72	
24009772-5	2013	Additionally rapamycin, a known inhibitor of mTOR-dependent protein synthesis, rescued cells from metformin-induced apoptosis and down-regulated CHOP expression.	Sirolimus	13-22	DNA damage inducible transcript 3	Homo sapiens	145-149