PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20003889-6 2009 To our knowledge, this is the first report demonstrating that levels of proteins in DHFR-based bicistronic constructs can be induced and modulated using MTX and rapamycin treatment. Sirolimus 161-170 dihydrofolate reductase Homo sapiens 84-88 10318894-2 1999 We describe a dominant clonal-selection assay of stably transfected cells expressing partner proteins FKBP (FK506 binding protein) and FRAP (FKBP-rapamycin binding protein) fused to DHFR fragments and show a rapamycin dose-dependent survival of clones that requires approximately 25 molecules of reconstituted DHFR per cell. Sirolimus 146-155 dihydrofolate reductase Homo sapiens 182-186