PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31624262-5 2019 Interestingly, numbers of IFN-gamma+ CD4+ T cells and serum IFN-gamma levels increased with the addition of sirolimus treatment likely promoting ongoing anti-PD-1 efficacy. Sirolimus 108-117 interferon gamma Homo sapiens 26-35 32670280-16 2020 Inhibition of mTOR in purified NK cells from healthy donors by rapamycin decreased the synthesis of IFN-gamma. Sirolimus 63-72 interferon gamma Homo sapiens 100-109 33949684-6 2021 We show that both Tregs and RA+ Tregs could be expanded in large numbers and the presence of rapamycin is essential to inhibit the growth of IFN-gamma producing cells. Sirolimus 93-102 interferon gamma Homo sapiens 141-150 33329581-7 2020 Rapamycin induced IFN-gamma-producing T-bet+Foxp3lo cells accompanied with enhanced lipid metabolism, whereas 2DG induced IFN-gamma-non-producing T-bet+Foxp3hi cells. Sirolimus 0-9 interferon gamma Homo sapiens 18-27 33013932-7 2020 In addition, rapamycin abrogated the ability of both DC subtypes to promote the proliferation and differentiation of IFN-y and Granzyme B producing CD8 + T cells. Sirolimus 13-22 interferon gamma Homo sapiens 117-122 31624262-5 2019 Interestingly, numbers of IFN-gamma+ CD4+ T cells and serum IFN-gamma levels increased with the addition of sirolimus treatment likely promoting ongoing anti-PD-1 efficacy. Sirolimus 108-117 interferon gamma Homo sapiens 60-69 30061014-9 2018 Inhibition of mTORC1 pathway with rapamycin, increase Tregs and decrease effector CD4+IFNgamma+, CD4+IL17+ and CD4+IL21+ T cells in patients with LVV. Sirolimus 34-43 interferon gamma Homo sapiens 86-94 27350635-7 2016 RESULTS: The mean absorbance of 10 out of the 12 studied cytokines showed reduction after the therapy with rapamycin including IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, IFN-gamma and TNF-alpha. Sirolimus 107-116 interferon gamma Homo sapiens 179-188 29895377-8 2018 In contrast to cyclosporine A and dexamethasone, only zinc aspartate and rapamycin were capable of suppressing the proliferation and Th1 (IFN-gamma), Th2 (IL-5), and Th17 (IL-17) cytokine production of pre-activated T cells. Sirolimus 73-82 interferon gamma Homo sapiens 138-147 27076449-5 2016 Rapamycin enhanced expansion of peripheral antigen-specific CD8 T cells and IFNgamma production following ex vivo antigen stimulation. Sirolimus 0-9 interferon gamma Homo sapiens 76-84 27076449-7 2016 Rapamycin increased IFNgamma production capacity in peripheral and tumor-infiltrating CD8 T cells. Sirolimus 0-9 interferon gamma Homo sapiens 20-28 27076449-9 2016 Rapamycin also enhanced IFNgamma or PD-L1 mAb treatment-associated induction of MHC class I expression on MOC1 tumor cells, an effect abrogated by depleting infiltrating CD8 T cells from the tumor microenvironment. Sirolimus 0-9 interferon gamma Homo sapiens 24-32 27350635-11 2016 CONCLUSION: Based on the findings of this study, rapamycin has some immunosuppressive effects, such as decreasing IFN -gamma, which can improve the quality of life of the patients with multiple sclerosis. Sirolimus 49-58 interferon gamma Homo sapiens 114-124 24434865-6 2014 All three immunosuppressive drugs inhibited the production of IL-2 equally well, whereas the production of IFN-gamma was less well inhibited by rapamycin. Sirolimus 144-153 interferon gamma Homo sapiens 107-116 25457208-8 2015 Moreover, ethanol (100 mM) and acetaldehyde (100 and 500 muM) increased levels of IL-6 and IFN-gamma, and suppressed autophagy in VA-13 cells, effects which were markedly alleviated by rapamycin. Sirolimus 185-194 interferon gamma Homo sapiens 91-100 24602288-11 2014 Rapamycin treatment significantly improved the neurobehavioral deficit after ICH, increased the number of Tregs, increased levels of interleukin-10 and transforming growth factor-beta and reduced interferon-gamma both in peripheral blood and brain. Sirolimus 0-9 interferon gamma Homo sapiens 196-212 24683191-9 2014 IFN-gamma expression was reduced in all lupus T cell subsets (p = 1.0 x 10(-5)) and also resisted rapamycin. Sirolimus 98-107 interferon gamma Homo sapiens 0-9 23968562-4 2013 Rapamycin inhibited the ability of both TLR-7-activated and TLR-9-activated PDC to stimulate production of IFN-gamma and interleukin (IL)-10 by allogeneic T cells. Sirolimus 0-9 interferon gamma Homo sapiens 107-116 24034707-8 2013 Thus, lack of inhibitory NK cell function during allo-specific T cell activation by human ICC + IFN-gamma-stimulated RAPA-DC may represent an unwanted effector mechanism that may underlie RAPA-induced inflammatory events in transplant patients undergoing microbial infection or allograft rejection. Sirolimus 117-121 interferon gamma Homo sapiens 96-105 21722526-8 2011 ELISA detection manifested that compared with the untreated group different concentrations of RPM could significantly inhibit the IL-2 and IFN-gamma secretion and significantly inhibited T lymphocyte proliferation (P<0.01). Sirolimus 94-97 interferon gamma Homo sapiens 139-148 19596836-8 2009 Re-expression of TSC2 or treatment with rapamycin inhibited IFN-gamma-induced STAT3 phosphorylation and synergized with IFN-gamma in inhibiting TSC2-null and LAMD cell proliferation. Sirolimus 40-49 interferon gamma Homo sapiens 60-69 19596836-8 2009 Re-expression of TSC2 or treatment with rapamycin inhibited IFN-gamma-induced STAT3 phosphorylation and synergized with IFN-gamma in inhibiting TSC2-null and LAMD cell proliferation. Sirolimus 40-49 interferon gamma Homo sapiens 120-129 16427044-9 2006 Simultaneously, treatment with LY294002, PD98059, or rapamycin abolished IFN-gamma-induced apoptosis in M12 cells. Sirolimus 53-62 interferon gamma Homo sapiens 73-82 19424019-8 2009 In conclusion, lymphopenia-induced IL-7 production after induction with ATG and sirolimus might lead to emergence of IFN-gamma-secreting CD8+ T-cells responsible for acute rejection after immunosuppression withdrawal. Sirolimus 80-89 interferon gamma Homo sapiens 117-126 19954658-7 2009 (3) On exposure to RAPA, the levels of p-mTOR, p-S6 and IFN-gamma in T cells in refractory/relapsed AA patients were significantly lower than those before the exposure (all P < 0.05). Sirolimus 19-23 interferon gamma Homo sapiens 56-65 19019941-8 2009 CONCLUSIONS: This study indicates that both RAPA and DEX inhibit the production of IL-17 and IFN-gamma by PBMCs. Sirolimus 44-48 interferon gamma Homo sapiens 93-102 17719815-8 2008 The IGFBP-3-promoted apoptosis in the presence of IFN-gamma could also be abrogated by blockade of the mTOR pathway with its pharmacological inhibitors, LY294002 or rapamycin. Sirolimus 165-174 interferon gamma Homo sapiens 50-59 16427044-7 2006 The IFN-gamma-induced dephosphorylation of pY-STAT3, however, was inhibited when the mTOR pathway was specifically blocked by rapamycin. Sirolimus 126-135 interferon gamma Homo sapiens 4-13 15996247-8 2005 Pre-transplant donor-directed IFN-gamma ELISPOT assessment of anti-donor cellular immunity may function as a "cellular crossmatch" and independently correlates with renal allograft function in African Americans receiving tacrolimus- and sirolimus-based immunosuppression. Sirolimus 237-246 interferon gamma Homo sapiens 30-39 12807916-9 2003 Thus, LPS and IFN-gamma activate the PI3K and mTOR pathways, which converge to regulate STAT1-dependent transcription of pro-apoptotic and pro-inflammatory genes in a rapamycin-insensitive manner. Sirolimus 167-176 interferon gamma Homo sapiens 14-23 15150095-5 2004 A combination of IFN-gamma and rapamycin is markedly synergistic in induction of apoptosis in Tsc1 or Tsc2 null cells because pSTAT3 Tyr705 phosphorylation is abolished completely and the other effects of IFN-gamma are maintained or enhanced. Sirolimus 31-40 interferon gamma Homo sapiens 205-214 15150095-6 2004 Rapamycin-IFN-gamma has unique potential therapeutic benefit for management of TSC tumors. Sirolimus 0-9 interferon gamma Homo sapiens 10-19 15522880-3 2005 In this report, we demonstrate that the IL-12-induced CsA-resistant pathway of IFN-gamma production is sensitive to rapamycin. Sirolimus 116-125 interferon gamma Homo sapiens 79-88 12176411-0 2002 Inhibition of IL-12 signaling Stat4/IFN-gamma pathway by rapamycin is associated with impaired dendritic [correction of dendritc] cell function. Sirolimus 57-66 interferon gamma Homo sapiens 36-45 10749688-13 2000 PDE4A4 was also selectively activated by challenge of U937 cells with either bacterial lipopolysaccharide (LPS) or IFN-gamma through a process which was attenuated by both wortmannin and rapamycin. Sirolimus 187-196 interferon gamma Homo sapiens 115-124 34551966-8 2021 Our results show that TLR-4-induced IFN-gamma production is regulated by the ribosomal protein S6 kinase (p70S6K) through the activation of PI3K, the mammalian target of rapamycin complex 1/2 (mTORC1/2), and the JNK MAPK pathways. Sirolimus 170-179 interferon gamma Homo sapiens 36-45 34561230-5 2021 IFN-gamma stimulation conferred on M0 macrophages the sensitivity to SM-induced cell death through the Jak/STAT, IFN regulatory factor-1, and mammalian target of rapamycin complex-1 (mTORC-1)/ribosomal protein S6 kinase pathways. Sirolimus 162-171 interferon gamma Homo sapiens 0-9 35563682-8 2022 Rapa-pretreated cells, but not 3-MA-pretreated cells, further amplified COX2 and IL-6 transcripts following IFNgamma exposure, and both groups upregulated secretion of prostaglandin-E2 (PGE2), the enzymatic product of COX2. Sirolimus 0-4 interferon gamma Homo sapiens 108-116 9190906-3 1997 However, a third immunosuppressive drug, rapamycin, normally associated with inhibiting the effects, but not the production, of cytokines, inhibited IL-10, but not IFN-gamma, production. Sirolimus 41-50 interferon gamma Homo sapiens 164-173 34956168-8 2021 This was further confirmed by the finding that both inhibitors of PI3K-Akt and its main downstream signaling mTOR, LY294002, and rapamycin, respectively, can reverse the increase of IFN-gamma production and cytotoxicity in NK cells promoted by Daphnetin. Sirolimus 129-138 interferon gamma Homo sapiens 182-191