PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18644437-3	2008	Drugs like rapamycin, that induce autophagy, increase the clearance of mutant huntingtin fragments and ameliorate the pathology in cell and animal models of HD and related conditions.	Sirolimus	11-20	huntingtin	Drosophila melanogaster	78-88	
17486044-5	2007	These SMERs, which seem to act either independently or downstream of the target of rapamycin, attenuated mutant huntingtin-fragment toxicity in Huntington"s disease cell and Drosophila melanogaster models, which suggests therapeutic potential.	Sirolimus	83-92	huntingtin	Drosophila melanogaster	112-122	
16497721-3	2006	We previously showed that rapamycin protects against mutant huntingtin-induced neurodegeneration in cell, fly and mouse models of Huntington"s disease [Ravikumar, B., Duden, R. and Rubinsztein, D.C. (2002) Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.	Sirolimus	26-35	huntingtin	Drosophila melanogaster	60-70	
17118264-8	2006	We showed that the autophagy inducer rapamycin reduced the levels of soluble and aggregated huntingtin and attenuated its toxicity in cells, and in transgenic Drosophila and mouse models.	Sirolimus	37-46	huntingtin	Drosophila melanogaster	92-102	
16368705-2	2006	Previously, we showed that rapamycin, an autophagy inducer, enhances mutant huntingtin fragment clearance and attenuated toxicity.	Sirolimus	27-36	huntingtin	Drosophila melanogaster	76-86