PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27278252-7 2016 However, treatment of tuberin-deficient cells with rapamycin showed significant decrease in protein expression of all Nox. Sirolimus 51-60 TSC complex subunit 2 Rattus norvegicus 22-29 18094073-7 2008 However, the re-expression of TSC2 or inhibition of mTOR/S6K1 with rapamycin (sirolimus) augmented antiproliferative effects of IFNbeta in LAM and TSC2-null ELT3 cells. Sirolimus 78-87 TSC complex subunit 2 Rattus norvegicus 147-151 27078846-8 2016 In addition, rapamycin in combination with celecoxib, a COX2 inhibitor, strongly inhibited Tsc2-deficient cell growth. Sirolimus 13-22 TSC complex subunit 2 Rattus norvegicus 91-95 16595860-2 2006 In addition, the role of rapamycin, an antagonist of the molecular target of rapamycin, in the morphological changes of spine caused by TSC2 silencing was investigated. Sirolimus 25-34 TSC complex subunit 2 Rattus norvegicus 136-140 16595860-7 2006 However, rapamycin treatment could reverse the effect of TSC2-RNAi on spine length but not on spine density. Sirolimus 9-18 TSC complex subunit 2 Rattus norvegicus 57-61 15557109-6 2005 Previous work has shown that a specific mTOR inhibitor, rapamycin, effectively down-regulated mTOR activity in renal tumors of Eker rats that carry a germline Tsc2 mutation. Sirolimus 56-65 TSC complex subunit 2 Rattus norvegicus 159-163 16322235-7 2005 Both baseline and PDGF-induced O2*- levels were significantly higher in TSC2-/- cells and were reduced by treatment with rapamycin and inhibitors of mitochondrial electron transport. Sirolimus 121-130 TSC complex subunit 2 Rattus norvegicus 72-76 15557109-10 2005 Rapamycin also resulted in a significant decrease in the size of the Tsc2-related renal tumors. Sirolimus 0-9 TSC complex subunit 2 Rattus norvegicus 69-73