PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1376003-3	1992	A 59-kilodalton member of the FK506- and rapamycin-binding class was found to associate in the absence of these drugs with two heat shock proteins (hsp90 and hsp70) and the glucocorticoid receptor (GR).	Sirolimus	41-50	heat shock protein 90 alpha family class A member 1	Homo sapiens	148-153	
18594209-3	2008	We now report that Akt activation in response to rapamycin is abrogated by 17-allylamino-17-demethoxygeldanamycin (17-AAG), a heat shock protein 90 (HSP90) inhibitor.	Sirolimus	49-58	heat shock protein 90 alpha family class A member 1	Homo sapiens	126-147	
19148492-11	2009	Rapamycin also down-regulated the activity of p70S6, pAkt and p-mTOR, but had no effect on pGSK-3beta, p44Erk, pCdc2, TSC1/2 or Hsp70 or Hsp90.	Sirolimus	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	137-142	
25714412-4	2015	Here, we report on the induction of autophagy initiated by the pathogen receptor HSP90AA1 (heat shock protein 90 kDa alpha [cytosolic], class A member 1) via the AKT-MTOR (mechanistic target of rapamycin)-dependent pathway.	Sirolimus	194-203	heat shock protein 90 alpha family class A member 1	Homo sapiens	81-89	
25714412-4	2015	Here, we report on the induction of autophagy initiated by the pathogen receptor HSP90AA1 (heat shock protein 90 kDa alpha [cytosolic], class A member 1) via the AKT-MTOR (mechanistic target of rapamycin)-dependent pathway.	Sirolimus	194-203	heat shock protein 90 alpha family class A member 1	Homo sapiens	91-152	
23255002-6	2013	We also found that the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) or arsenic trioxide (ATO) in combination with rapamycin markedly inhibited the growth of MCF-7 cells and 17-AAG or ATO suppressed rapamycin-induced phosphorylation of Akt.	Sirolimus	133-142	heat shock protein 90 alpha family class A member 1	Homo sapiens	23-28	
23255002-6	2013	We also found that the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) or arsenic trioxide (ATO) in combination with rapamycin markedly inhibited the growth of MCF-7 cells and 17-AAG or ATO suppressed rapamycin-induced phosphorylation of Akt.	Sirolimus	217-226	heat shock protein 90 alpha family class A member 1	Homo sapiens	23-28	
18594209-3	2008	We now report that Akt activation in response to rapamycin is abrogated by 17-allylamino-17-demethoxygeldanamycin (17-AAG), a heat shock protein 90 (HSP90) inhibitor.	Sirolimus	49-58	heat shock protein 90 alpha family class A member 1	Homo sapiens	149-154	
18594209-8	2008	Rapamycin/17-AAG combination alleviates the induction of HSP90 protein, a heat shock response frequently associated with 17-AAG monotherapy.	Sirolimus	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	57-62