PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28648781-6 2017 Ceramides synergize with rapamycin, a TORC1 inhibitor, in counteracting the DDR. Sirolimus 25-34 CREB regulated transcription coactivator 1 Homo sapiens 38-43 34880790-13 2021 A decreased level of TORC1-the mechanistic target of the rapamycin complex, suggests a possible future approach to therapy in FXTAS. Sirolimus 57-66 CREB regulated transcription coactivator 1 Homo sapiens 21-26 34638732-8 2021 The results confirmed the elevation of AMPK and mitochondrial respiratory activities and reduction in reactive O2 species (ROS) levels in premutation cells and revealed for the first time that target of rapamycin complex I (TORC1) activities are reduced. Sirolimus 203-212 CREB regulated transcription coactivator 1 Homo sapiens 224-229 33740659-1 2021 The degradation of nucleolar proteins - nucleophagy - is elicited by nutrient starvation or the inactivation of target of rapamycin complex 1 (TORC1) protein kinase in budding yeast. Sirolimus 122-131 CREB regulated transcription coactivator 1 Homo sapiens 143-148 33157024-2 2021 At lysosomes and endosomes, the Fab1 lipid kinase complex and the nutrient-regulated target of rapamycin complex 1 (TORC1) control the integrity of the endolysosomal homeostasis and cellular metabolism. Sirolimus 95-104 CREB regulated transcription coactivator 1 Homo sapiens 116-121 33445779-1 2021 Target of rapamycin complex 1 (TORC1), a serine/threonine-protein kinase complex highly conserved among eukaryotes, coordinates cellular growth and metabolism with environmental cues, including nutrients and growth factors. Sirolimus 10-19 CREB regulated transcription coactivator 1 Homo sapiens 31-36 33744865-4 2021 We previously showed that myriocin, which impairs sphingolipid synthesis, increases lifespan in Saccharomyces cerevisiae by modulating signaling pathways including the target of rapamycin complex 1 (TORC1). Sirolimus 178-187 CREB regulated transcription coactivator 1 Homo sapiens 199-204 31546204-4 2019 Rapamycin is an inhibitor of mammalian TORC1 (target of rapamycin complex-1) and used in the treatment of some diseases like cancer, cardiovascular and neurological diseases. Sirolimus 0-9 CREB regulated transcription coactivator 1 Homo sapiens 39-44 31546204-4 2019 Rapamycin is an inhibitor of mammalian TORC1 (target of rapamycin complex-1) and used in the treatment of some diseases like cancer, cardiovascular and neurological diseases. Sirolimus 0-9 CREB regulated transcription coactivator 1 Homo sapiens 46-75 29062000-6 2017 Further analysis of the Gap1 permease showed that FTY720 elicits its ubiquitylation via the same factors that promote this modification when TORC1 is inhibited by rapamycin. Sirolimus 163-172 CREB regulated transcription coactivator 1 Homo sapiens 141-146 27153139-9 2016 The use of Rapamycin (TORC1 inhibitor) was able on one hand to increase TFEB activation and, on the other hand, to reduce lipofuscin mass, potentiating the lysosomal functionality. Sirolimus 11-20 CREB regulated transcription coactivator 1 Homo sapiens 22-27 27065332-7 2016 Interestingly, while inhibition of PI-3K and AKT lowers 4E-BP1 phosphorylation and expression of Id1 in all cases, inhibition of TORC1 with rapamycin does not consistently have a similar effect, suggesting an alternative mechanism for PI-3K-dependent regulation of Id1 translation. Sirolimus 140-149 CREB regulated transcription coactivator 1 Homo sapiens 129-134 26147250-2 2015 Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. Sirolimus 0-9 CREB regulated transcription coactivator 1 Homo sapiens 35-40 26452980-6 2015 Notably, INK128 was more potent than the TORC1 inhibitor rapamycin in down-regulating Mcl-1, diminishing AKT and 4EBP1 phosphorylation, and potentiating ABT-737 activity. Sirolimus 57-66 CREB regulated transcription coactivator 1 Homo sapiens 41-46 27161823-2 2016 Although both complexes are evolutionarily conserved, only TORC1 is acutely inhibited by rapamycin. Sirolimus 89-98 CREB regulated transcription coactivator 1 Homo sapiens 59-64 25073740-4 2014 TORC1 inactivation, via nitrogen deprivation or rapamycin treatment, changes cellular levels of SEA complex members. Sirolimus 48-57 CREB regulated transcription coactivator 1 Homo sapiens 0-5 26024867-3 2015 Rapamycin inhibition of TorC1 elicits nuclear localization of Gln3, a GATA-family transcription activator responsible for the expression of genes encoding proteins required to transport and degrade poor nitrogen sources, e.g., proline. Sirolimus 0-9 CREB regulated transcription coactivator 1 Homo sapiens 24-29 24344203-4 2014 We show here that the sensitivity to rapamycin is mediated via inhibition of TORC1 and suppressed by overexpression of isp7(+), a member of the family of 2-oxoglutarate-Fe(II)-dependent oxygenase genes. Sirolimus 37-46 CREB regulated transcription coactivator 1 Homo sapiens 77-82 24970820-2 2014 In such cells, as well as in yeast, the selective TORC1 inhibitor rapamycin blocks this activation in contrast to Hsp90 inhibitors which potently activate Hsf1. Sirolimus 66-75 CREB regulated transcription coactivator 1 Homo sapiens 50-55 24718867-4 2014 EXPERIMENTAL DESIGN: We tested the efficacy of imatinib or PLX3397 either alone or in combination with TORC1 inhibitor rapamycin in a cell proliferation assay in vitro and by immunoblotting to determine target inhibition. Sirolimus 119-128 CREB regulated transcription coactivator 1 Homo sapiens 103-108 23117620-4 2013 The dephosphorylating activity of ferulic acid was almost comparable to that of rapamycin, an established mTor inhibitor (TORC1). Sirolimus 80-89 CREB regulated transcription coactivator 1 Homo sapiens 122-127 23689994-2 2013 Palomid 529, an investigational medication involving the immune Akt/mTOR pathway, is unique in dissociating both targets of rapamycin complexes TORC1 and TORC2. Sirolimus 124-133 CREB regulated transcription coactivator 1 Homo sapiens 144-149 23826334-5 2013 Wild type levels of tunicamycin sensitivity were restored in iph1 null cells when the TORC1 complex was inhibited by rapamycin or by heat inactivation of the Tor2 kinase. Sirolimus 117-126 CREB regulated transcription coactivator 1 Homo sapiens 86-91 23184930-7 2013 Alteration of the alphacap significantly diminished the response of Ure2 dephosphorylation to the TorC1 inhibitor, rapamycin. Sirolimus 115-124 CREB regulated transcription coactivator 1 Homo sapiens 98-103 23935103-1 2013 Five different physiological conditions have been used interchangeably to establish the sequence of molecular events needed to achieve nitrogen-responsive down-regulation of TorC1 and its subsequent regulation of downstream reporters: nitrogen starvation, methionine sulfoximine (Msx) addition, nitrogen limitation, rapamycin addition, and leucine starvation. Sirolimus 316-325 CREB regulated transcription coactivator 1 Homo sapiens 174-179 23601176-4 2013 By combining a low dose of rapamycin, to reduce activity of the target of rapamycin complex 1 (TORC1) protein kinase, and myriocin, to reduce sphingolipid synthesis, we show enhancement of autophagy, genomic stability, mitochondrial function, and AMP kinase pathway activity. Sirolimus 27-36 CREB regulated transcription coactivator 1 Homo sapiens 64-93 23601176-4 2013 By combining a low dose of rapamycin, to reduce activity of the target of rapamycin complex 1 (TORC1) protein kinase, and myriocin, to reduce sphingolipid synthesis, we show enhancement of autophagy, genomic stability, mitochondrial function, and AMP kinase pathway activity. Sirolimus 27-36 CREB regulated transcription coactivator 1 Homo sapiens 95-100 20072130-2 2010 The mTOR kinase functions in two complexes, TORC1 (target of rapamycin complex-1) and TORC2 (target of rapamycin complex-2); however, neither of these complexes is fully inhibited by the allosteric inhibitor rapamycin or its analogs. Sirolimus 61-70 CREB regulated transcription coactivator 1 Homo sapiens 44-49 21317285-5 2011 Inhibition of TORC1 by rapamycin treatment resulted in the accumulation of stage IV melanosomes but not autophagosomes, whereas starvation resulted in the formation of autophagosomes but not melanin accumulation. Sirolimus 23-32 CREB regulated transcription coactivator 1 Homo sapiens 14-19 20404504-5 2010 In addition, cells overexpressing the active form of Plk1 were characterized by abnormal growth that could be reversed by rapamycin, a specific inhibitor of the TORC1 complex. Sirolimus 122-131 CREB regulated transcription coactivator 1 Homo sapiens 161-166 19374918-1 2009 Sirolimus is a member of a novel class of immunosuppressant drug that potently suppresses T cell proliferation and expansion by inhibition of the Target of Rapamycin Complex 1 (TORC1) protein kinase. Sirolimus 0-9 CREB regulated transcription coactivator 1 Homo sapiens 146-175 20549474-8 2010 These inhibitors bind to the ATP binding site of the kinase domain of mTOR and as a result inhibit both mTOR complexes, TORC1 (rapamycin sensitive) and TORC2 (rapamycin resistant). Sirolimus 127-136 CREB regulated transcription coactivator 1 Homo sapiens 120-125 19586661-3 2009 The immunosuppressive/anti-cancer agent rapamycin inhibits TORC1 function by disrupting the mTOR-raptor interaction. Sirolimus 40-49 CREB regulated transcription coactivator 1 Homo sapiens 59-64 19374918-1 2009 Sirolimus is a member of a novel class of immunosuppressant drug that potently suppresses T cell proliferation and expansion by inhibition of the Target of Rapamycin Complex 1 (TORC1) protein kinase. Sirolimus 0-9 CREB regulated transcription coactivator 1 Homo sapiens 177-182 19374918-5 2009 In polycystic kidney disease, TORC1 activation mediates renal tubular epithelial cell (TEC) proliferation and cyst growth in animals, and Phase III clinical trials are underway to determine the effect of sirolimus in attenuating disease progression in humans. Sirolimus 204-213 CREB regulated transcription coactivator 1 Homo sapiens 30-35 19100909-7 2008 Mammalian TORC1 (mTORC1) is rapamycin sensitive and contains mTOR, raptor, and mLST8. Sirolimus 28-37 CREB regulated transcription coactivator 1 Homo sapiens 10-15 16627617-3 2006 TORC1, which is sensitive to rapamycin, regulates translation and cell growth, whereas TORC2, which is insensitive to rapamycin, regulates cell morphology and cell growth. Sirolimus 29-38 CREB regulated transcription coactivator 1 Homo sapiens 0-5