PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34905649-8	2022	Mechanistically, GDF11 significantly activates mammalian target of rapamycin complex 1 (mTORC1) and subsequently represses transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy.	Sirolimus	67-76	transcription factor EB	Homo sapiens	123-146	
35020443-2	2022	The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at multiple sites including Ser-211.	Sirolimus	73-82	transcription factor EB	Homo sapiens	28-32	
35020443-2	2022	The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at multiple sites including Ser-211.	Sirolimus	73-82	transcription factor EB	Homo sapiens	131-135	
30546014-2	2018	TFEB activity is inhibited following its phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) on the surface of the lysosome.	Sirolimus	80-89	transcription factor EB	Homo sapiens	0-4	
33163944-4	2020	Here, we show that under pharmacological and genetic c-Abl inhibition, TFEB translocates into the nucleus promoting the expression of its target genes independently of its well-known regulator, mammalian target of rapamycin complex 1.	Sirolimus	214-223	transcription factor EB	Homo sapiens	71-75	
26377470-5	2015	Treatment with rapamycin was found to independently restore PGC1alpha-TFEB signaling in a manner not requiring parkin activity and to abrogate impairment of mitochondrial quality control and neurodegenerative features associated with this in vivo model.	Sirolimus	15-24	transcription factor EB	Homo sapiens	70-74	
27153139-9	2016	The use of Rapamycin (TORC1 inhibitor) was able on one hand to increase TFEB activation and, on the other hand, to reduce lipofuscin mass, potentiating the lysosomal functionality.	Sirolimus	11-20	transcription factor EB	Homo sapiens	72-76	
27112200-7	2016	The activation of autophagy including TFEB is likely due to fisetin-mediated mammalian target of rapamycin complex 1 (mTORC1) inhibition, since the phosphorylation levels of p70S6 kinase and 4E-BP1 were decreased in the presence of fisetin.	Sirolimus	97-106	transcription factor EB	Homo sapiens	38-42	
26377470-12	2015	Treatment with rapamycin independently restores PGC1alpha-TFEB signaling in a manner not requiring parkin activity and abrogates subsequent mitochondrial impairment and neuronal cell loss.	Sirolimus	15-24	transcription factor EB	Homo sapiens	58-62