PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29579719-7	2018	Finally, we demonstrated that the restoration/preservation of autophagic-lysosomal degradation in senescent MEFs following rapamycin treatment correlated with attenuation of copper accumulation in these cells despite a further decrease in Atp7a levels.	Sirolimus	123-132	ATPase copper transporting alpha	Homo sapiens	239-244	
31921404-0	2020	TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.	Sirolimus	108-117	ATPase copper transporting alpha	Homo sapiens	126-129	
31921404-12	2020	Our data showing upregulation of these signaling pathways by rapamycin support a strategy to combine a MEK or a MNK inhibitor with rapamycin that may be superior for TSC-associated CNS defects.	Sirolimus	61-70	ATPase copper transporting alpha	Homo sapiens	112-115	
21949767-12	2011	MNK kinase mediated the eIF4E phosphorylation and inhibition or depletion of MNK markedly suppressed proliferation of the CTCL cells when combined with the rapamycin-mediated inhibition of mTORC1.	Sirolimus	156-165	ATPase copper transporting alpha	Homo sapiens	0-3	
27050281-3	2016	Rapamycin induces eIF4E phosphorylation by activating MAPK-interacting kinases (Mnks), and therefore targeting Mnk/eIF4E pathway represents a potential therapeutic strategy for the treatment of NSCLC.	Sirolimus	0-9	ATPase copper transporting alpha	Homo sapiens	80-83	
25527453-7	2015	In KYO-1 cells where Akt is not constitutively active, Mnk inhibitors increase the sensitivity of cells to rapamycin, resulting in a more pronounced anti-proliferative activity.	Sirolimus	107-116	ATPase copper transporting alpha	Homo sapiens	55-58	
28665070-8	2017	In an ATP7A knock-out model, rapamycin treatment synergistically inhibited cell viability, wound healing, and invasion ability compared to rapamycin only.	Sirolimus	29-38	ATPase copper transporting alpha	Homo sapiens	6-11	
20664001-7	2010	It is noteworthy that the mammalian target of rapamycin (mTOR) inhibitor rapamycin also induced phosphorylation of eIF4E in a Mnk-dependent manner, whereas inhibition strongly enhanced its antileukemic effects.	Sirolimus	46-55	ATPase copper transporting alpha	Homo sapiens	126-129