PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33846885-8	2021	RAPA restored NF-kappaB and HIF-1alpha to normal levels.	Sirolimus	0-4	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	28-38	
30050390-6	2018	Results: Rapamycin alleviated the pathological damage of myocardial tissue, attenuated cardiac dysfunction (left ventricular ejection fraction (LVEF), p < 0.05; fractional shortening (FS), p < 0.05), and reduced HIF-1a expression (p < 0.05).	Sirolimus	9-18	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	218-224	
32800663-10	2020	PD-L1 expression was suppressed significantly when the HIF-1alpha inhibitor rapamycin was added to the culture medium (P = .024).	Sirolimus	76-85	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	55-65	
33641344-5	2021	Inhibition of mTOR by rapamycin blocked phosphorylated form of ribosomal protein S6, NF-kappaB p65 activity by increasing degradation of IkappaB-alpha in parallel with HIF-1alpha expression increased by LPS in the kidney, heart, lung, and brain tissues.	Sirolimus	22-31	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	168-178	
29893708-6	2018	In addition, compared with rats in the Rapamycin + TAE group, N-cadherin, Vimentin, HIF-1alpha, VEGF, and MVD-CD34 were obviously enhanced, while E-cadherin was lowered in those TAE group, which were the complete opposite to the Rapamycin group.	Sirolimus	39-48	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	84-94	
23635649-9	2013	Both wortmannin and rapamycin inhibited isoflurane-induced phospho-4E-BP1 (Ser 65) and phospho-P70(s6k) (Thr 389) and HIF-1alpha expression.	Sirolimus	20-29	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	118-128	
27997905-7	2016	Blocking mTOR by using rapamycin significantly attenuated activities of HIF-1alpha and VEGF signaling pathways.	Sirolimus	23-32	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	72-82	
22178140-9	2012	Furthermore, pretreatment with rapamycin, a mTOR specific inhibitor, significantly inhibited HIF-1alpha and VEGF protein after HI.	Sirolimus	31-40	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	93-103	
18216782-5	2008	Rapamycin attenuated DC differentiation, HIF-1alpha expression, and its target gene expression in a dose-dependent manner along with downregulated interleukin-10 secretion.	Sirolimus	0-9	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	41-51	
18651560-13	2008	Rapamycin or cycloheximide, blocked increased HIF-1alpha levels during re-oxygenation indicating that mTOR-dependent protein synthesis is required for the persistent elevation of HIF-1alpha levels during re-oxygenation.	Sirolimus	0-9	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	46-56	
18651560-13	2008	Rapamycin or cycloheximide, blocked increased HIF-1alpha levels during re-oxygenation indicating that mTOR-dependent protein synthesis is required for the persistent elevation of HIF-1alpha levels during re-oxygenation.	Sirolimus	0-9	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	179-189	
20389030-6	2010	By Western blotting analysis, we observed decreased intracellular levels of VEGF and HIF-1alpha under octreotide, rapamycin and LY294002.	Sirolimus	114-123	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	85-95	
18216782-9	2008	Rapamycin attenuates the hypoxic immune-inflammatory response through inhibition of the HIF-1alpha pathway.	Sirolimus	0-9	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	88-98	
16506055-6	2006	The insulin-induced increase of HIF-1alpha is blunted by the translation inhibitor cycloheximide, LY294002, PD98059, SP600125 and rapamycin, but not by SB203580.	Sirolimus	130-139	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	32-42	
11834720-9	2002	Moreover, the stress-mediated induction of HIF-1alpha and VEGF was suppressed by gadolinium (a stretch-activated channel inhibitor), wortmannin, and rapamycin (a FRAP inhibitor).	Sirolimus	149-158	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	43-53