PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26061549-6 2015 Interestingly, the expression of Klotho, an antiaging gene that suppresses VC, was reduced in calcified vasculature, whereas rapamycin reversed membrane and secreted Klotho decline through mTOR inhibition. Sirolimus 125-134 klotho Homo sapiens 166-172 21672148-0 2011 Rapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expression. Sirolimus 0-9 klotho Homo sapiens 100-106 21672148-6 2011 Rapamycin treatment of an immortalized proximal tubular cell line induced the expression of Klotho, the phosphorylation of AKT in Ser473, downstream target of mTORC2 and the expression of RICTOR, mTORC2 main component. Sirolimus 0-9 klotho Homo sapiens 92-98