PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33206174-6	2021	Mechanistically, rapamycin inactivates carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase (CAD), the essential enzyme for the first three steps of de novo pyrimidine synthesis, and deteriorates CHIR-124-induced replicative stress.	Sirolimus	17-26	aconitate decarboxylase 1	Homo sapiens	122-125	
32974014-5	2020	Mechanistically, formate induces mechanistic target of rapamycin complex 1 (mTORC1) activity as quantified by phosphorylation of its targets S6, 4E-BP1, S6K1 and CAD.	Sirolimus	55-64	aconitate decarboxylase 1	Homo sapiens	162-165	
32974014-6	2020	Treatment with the allosteric mTORC1 inhibitor rapamycin abrogates CAD phosphorylation and pyrimidine synthesis induced by formate.	Sirolimus	47-56	aconitate decarboxylase 1	Homo sapiens	67-70