PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34859624-9 2021 RAPA could also enhance the relative protein expression of Beclin-1 and LC3-II (P<0.01), and reduce the expression of p-mTOR (P<0.01). Sirolimus 0-4 beclin 1 Homo sapiens 59-67 19864570-7 2009 In contrast, rapamycin enhanced the effects of beclin 1. Sirolimus 13-22 beclin 1 Homo sapiens 47-55 18398293-6 2008 Knocking down Beclin 1 markedly decreased the mitochondrial translocation of EGFR that was induced by rapamycin. Sirolimus 102-111 beclin 1 Homo sapiens 14-22 21646862-7 2011 The autophagy contributing to apoptosis was Beclin 1-independent, as shown by the fact that Beclin 1 knockdown failed to reduce it but efficiently reduced rapamycin-induced autophagy. Sirolimus 155-164 beclin 1 Homo sapiens 92-100 21350938-7 2011 Rapamycin at low concentrations might be insufficient to initiate autophagosome formation in autophagy but Beclin-1 overexpression triggered additional processes downstream of mTOR during G(1) cell cycle arrest by rapamycin. Sirolimus 214-223 beclin 1 Homo sapiens 107-115 20168088-4 2010 Rapamycin administration caused a significant reduction of 70 kDa S6 kinase (p70S6K) phosphorylation and a significant increase of the autophagic proteins Beclin 1 and microtubule-associated protein 1 light chain 3 (LC3), as of monodansylcadaverine (MDC) labeling in the lesioned side. Sirolimus 0-9 beclin 1 Homo sapiens 155-214 35356282-14 2022 Pre-treatment with rapamycin or PFT-alpha significantly down-regulated the levels of SA beta-Gal, SAHF, p-p53, p21, autophagy related protein p62, the percentage of cells in the G0/G1 phase, and significantly up-regulated DeltaPsim, autophagy related protein BECN1, autophagosomes and autolysosomes compared with cells only treated with AOPPs. Sirolimus 19-28 beclin 1 Homo sapiens 259-264 35589065-12 2022 Rapamycin restored the protein expression levels of beclin1, LC3-II/LC3-I and OCN, OPN, OSX under the high lactate conditions. Sirolimus 0-9 beclin 1 Homo sapiens 52-59 34454349-6 2021 Similarly, treatment with the autophagy activator rapamycin increased Beclin1 expression during OPG-induced inhibition of osteoclastogenesis. Sirolimus 50-59 beclin 1 Homo sapiens 70-77 33790644-10 2021 Notably, rapamycin increased the autophagy-related Beclin1 protein expression levels and the LC3 II/I ratio. Sirolimus 9-18 beclin 1 Homo sapiens 51-58 33423318-6 2021 In macrophages in-vitro, budesonide and simvastatin inhibited rapamycin-induced autophagy as well as autophagic flux, with reduced expression of beclin-1 and LC3, but enhanced the accumulation of p62 and increased expression of IL-10, which itself further inhibited autophagy in macrophages. Sirolimus 62-71 beclin 1 Homo sapiens 145-153 32116708-5 2020 The expressions of autophagy markers (ATG5, ATG7, Beclin-1, LC3 B) and the necroptosis marker RIPK3 increased and another necroptosis marker RIPK1 decreased after the combination treatment of rapamycin and MK-2206, and were accompanied by the morphological characteristics of autophagy and necroptosis. Sirolimus 192-201 beclin 1 Homo sapiens 50-58 32306690-11 2020 Compared with PQ group, the expression levels of autophagy-related proteins LC3II/LC3I and Beclin1 were significantly increased whlie alpha-synuclein protein level was decreased after RAPA induction (P<0.05) . Sirolimus 184-188 beclin 1 Homo sapiens 91-98 32114389-9 2020 Rapamycin, an autophagy activator, quantitatively and functionally improved BM ECs from PGF patients in vitro and enhanced their ability to support HSCs by activating the Beclin-1 pathway. Sirolimus 0-9 beclin 1 Homo sapiens 171-179 32231197-7 2020 RESULTS: Inhibition of mTOR by rapamycin could reverse glucocorticoid resistance in CEM-C1 cells, and also induce autophagy in these cells by up-regulation of LC3-II and Beclin-1 expressions. Sirolimus 31-40 beclin 1 Homo sapiens 170-178 32621911-7 2020 Compared with liraglutide group, treatment with rapamycin, a specific inhibitor of mTOR, compatibly augmented GLP-1 receptor level, inhibited phosphorylation of mTOR/p70S6K and expression of p62 as well as increased level of LC3-II/LC3-I ratio and Beclin-1, suggesting that there is an interaction between GLP-1 and mTOR/p70S6K signaling in the regulation of autophagy. Sirolimus 48-57 beclin 1 Homo sapiens 248-256 32016998-5 2020 RESULTS: Compared with the Control group, Rapamycin group, and Rapamycin + Beclin-1 plasmid transfection group had markedly weakened the viability of MG-63 cells, inhibited cell proliferation, remarkably increased cell apoptosis rate, elevated Bax level, notably declined Bcl-2 level, and significantly raised the levels of Beclin-1 and Vps34 proteins in MG-63 cells. Sirolimus 63-72 beclin 1 Homo sapiens 75-83 32016998-5 2020 RESULTS: Compared with the Control group, Rapamycin group, and Rapamycin + Beclin-1 plasmid transfection group had markedly weakened the viability of MG-63 cells, inhibited cell proliferation, remarkably increased cell apoptosis rate, elevated Bax level, notably declined Bcl-2 level, and significantly raised the levels of Beclin-1 and Vps34 proteins in MG-63 cells. Sirolimus 63-72 beclin 1 Homo sapiens 324-332 32962569-9 2020 The Beclin-1 protein expression of dexamethasone group was lower than those of rapamycin and dexamethasone- rapamycin groups (p<0.001), and the expression of rapamycin group exceeded that of dexamethasone-rapamycin group (p<0.05). Sirolimus 108-117 beclin 1 Homo sapiens 4-12 32962569-9 2020 The Beclin-1 protein expression of dexamethasone group was lower than those of rapamycin and dexamethasone- rapamycin groups (p<0.001), and the expression of rapamycin group exceeded that of dexamethasone-rapamycin group (p<0.05). Sirolimus 108-117 beclin 1 Homo sapiens 4-12 32962569-9 2020 The Beclin-1 protein expression of dexamethasone group was lower than those of rapamycin and dexamethasone- rapamycin groups (p<0.001), and the expression of rapamycin group exceeded that of dexamethasone-rapamycin group (p<0.05). Sirolimus 108-117 beclin 1 Homo sapiens 4-12 31315300-10 2019 The Western blot results showed that the expression levels of Beclin1, LC3-I/II, and ERK were significantly elevated in HEMA-treated cells and in cells co-treated with rapamycin, an autophagic promoter. Sirolimus 168-177 beclin 1 Homo sapiens 62-69 25342595-5 2015 Here, we show that NH4Cl significantly inhibited rapamycin-induced autophagy in HCC cells through decreasing the levels of Beclin-1, autophagy-related protein 7 (ATG7), p62, and autophagosome marker LC3 and significantly decreased the level of phosphorylated SMAD2 in rapamycin-treated HCC cells. Sirolimus 49-58 beclin 1 Homo sapiens 123-131 30195918-6 2018 In addition, rapamycin can induce autophagy in lamprey leukocytes and the deficiency of human Beclin1 protein can be rescued by lancelet and lamprey Beclin1 proteins. Sirolimus 13-22 beclin 1 Homo sapiens 94-101 30195918-6 2018 In addition, rapamycin can induce autophagy in lamprey leukocytes and the deficiency of human Beclin1 protein can be rescued by lancelet and lamprey Beclin1 proteins. Sirolimus 13-22 beclin 1 Homo sapiens 149-156 27832632-6 2016 Autophagy inhibition by 3-MA or CQ, or by shRNA silencing of Agt-7 or Beclin-1 reduced the protective effects of starvation and rapamycin on H2O2-treated hTSCs. Sirolimus 128-137 beclin 1 Homo sapiens 70-78 30747228-0 2019 Rapamycin-induced miR-30a downregulation inhibits senescence of VSMCs by targeting Beclin1. Sirolimus 0-9 beclin 1 Homo sapiens 83-90 30690083-6 2019 KEY FINDINGS: Rapamycin promoted autophagy and the X protein synthesis concomitantly with elevation in Akt phosphorylation and Beclin1 expression. Sirolimus 14-23 beclin 1 Homo sapiens 127-134 30393233-8 2018 The WB results showed that the expression levels of Beclin-1 and LC3-II/LC3-I were significantly elevated in NB cells treated with Rapamycin, while the expression levels of P62, mTOR, and p-mTOR proteins were significantly reduced compared with the control cells (P<0.05). Sirolimus 131-140 beclin 1 Homo sapiens 52-60 27521838-9 2016 Notably, in the basal condition, Beclin-1 was more elevated in MHUASMCs than in FHUASMCs, and the difference disappeared after serum starvation and exposure to rapamycin. Sirolimus 160-169 beclin 1 Homo sapiens 33-41 24462935-8 2014 The inhibition of Beclin 1 by siRNAs significantly attenuated the expression of autophagy-related proteins and reduced HUVEC viability following OGD and rapamycin treatment. Sirolimus 153-162 beclin 1 Homo sapiens 18-26 25375091-3 2014 The involvement of autophagy in rapamycin-induced KIT downregulation was further confirmed by co-localization of KIT and autophagosome, and partial recovery of KIT expression level by either siRNA-mediated BECN1 and ATG5 silencing or autophagy inhibitors after rapamycin. Sirolimus 32-41 beclin 1 Homo sapiens 206-211 24919871-5 2014 However, if the compounds were added to the cells 24 h before the viruses, GRA induced the production of an even higher amount of Beclin 1 and showed an improved antiviral effect; under these conditions, rapamycin was also able to exert a significant anti-HSV1 activity. Sirolimus 204-213 beclin 1 Homo sapiens 130-138 24205354-6 2013 Quantitation of acidic vesicular organelles confirmed that combination of LC3 shRNA plasmid transfection and GST treatment prevented rapamycin-induced autophagy due to down regulation of autophagy promoting marker molecules (LC3 II, Beclin 1, TLR-4, and Myd88) and upregulation of autophagy inhibiting marker molecules (p62 and mTOR) in both cell lines. Sirolimus 133-142 beclin 1 Homo sapiens 233-241 24587252-14 2014 Finally, Co-immunoprecipitation of Ambra1 and Beclin1 demonstrated that Ambra1 and Beclin1 interact in serum-starved or rapamycin-treated SW620 cells, suggesting that Ambra1 regulates autophagy in CRC cells by interacting with Beclin1. Sirolimus 120-129 beclin 1 Homo sapiens 46-53 24587252-14 2014 Finally, Co-immunoprecipitation of Ambra1 and Beclin1 demonstrated that Ambra1 and Beclin1 interact in serum-starved or rapamycin-treated SW620 cells, suggesting that Ambra1 regulates autophagy in CRC cells by interacting with Beclin1. Sirolimus 120-129 beclin 1 Homo sapiens 83-90 24587252-14 2014 Finally, Co-immunoprecipitation of Ambra1 and Beclin1 demonstrated that Ambra1 and Beclin1 interact in serum-starved or rapamycin-treated SW620 cells, suggesting that Ambra1 regulates autophagy in CRC cells by interacting with Beclin1. Sirolimus 120-129 beclin 1 Homo sapiens 83-90