PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31102490-5	2019	The interleukin (IL)-10/signal transducer and activator of transcription 3 anti-inflammatory pathway was downregulated in a Toll-like receptor 2-independent manner after rapamycin treatment and IL-10 replenishment abrogated the effects of rapamycin on inflammation and CESC apoptosis.	Sirolimus	170-179	toll like receptor 2	Homo sapiens	124-144	
26337526-0	2015	Down-regulation of mitogen-activated protein kinases and nuclear factor-kappaB signaling is involved in rapamycin suppression of TLR2-induced inflammatory response in monocytic THP-1 cells.	Sirolimus	104-113	toll like receptor 2	Homo sapiens	129-133	
27888296-9	2017	Finally, promoting autophagy with rapamycin or pharmacological inhibition of the TLR2 signaling pathway prevented the TLR2-mediated increase in alpha-synuclein in neuronal cell cultures.	Sirolimus	34-43	toll like receptor 2	Homo sapiens	118-122	
26337526-3	2015	Here, the mechanism by which rapamycin suppresses TLR2-induced inflammatory responses was investigated.	Sirolimus	29-38	toll like receptor 2	Homo sapiens	50-54	
26337526-8	2015	Additionally, western blot showed that pre-treatment of THP-1 cells with rapamycin down-regulates MAPKs and NF-kappaB signaling induced by Pam3CSK4 stimulation, suggesting that rapamycin suppresses Pam3CSK4-induced pro-inflammatory cytokines via inhibition of TLR2 signaling.	Sirolimus	73-82	toll like receptor 2	Homo sapiens	260-264	
26337526-8	2015	Additionally, western blot showed that pre-treatment of THP-1 cells with rapamycin down-regulates MAPKs and NF-kappaB signaling induced by Pam3CSK4 stimulation, suggesting that rapamycin suppresses Pam3CSK4-induced pro-inflammatory cytokines via inhibition of TLR2 signaling.	Sirolimus	177-186	toll like receptor 2	Homo sapiens	260-264	
26337526-9	2015	It was concluded that rapamycin suppresses TLR2-induced inflammatory responses by down-regulation of Erk and NF-kappaB signaling.	Sirolimus	22-31	toll like receptor 2	Homo sapiens	43-47	
22617154-8	2012	Furthermore, the antiviral activity of TLR2 ligands was abolished by pretreatment with U0126 and rapamycin, inhibitors of the MAPK/ERK and PI3K/Akt pathways, respectively.	Sirolimus	97-106	toll like receptor 2	Homo sapiens	39-43