PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35436937-9 2022 Correspondingly, the expressions of Nrf2, Atm, Atr, and Prkdc in IVM oocytes were markedly increased, following the inhibition of mTORC1 pathway by 10 nM rapamycin. Sirolimus 154-163 ataxia telangiectasia mutated Mus musculus 42-45 20160076-6 2010 Importantly, elevated ROS and dysregulation of mTORC1 in ATM-deficient cells is inhibited by rapamycin, which also rescues lymphomagenesis in Atm-deficient mice. Sirolimus 93-102 ataxia telangiectasia mutated Mus musculus 57-60 20160076-6 2010 Importantly, elevated ROS and dysregulation of mTORC1 in ATM-deficient cells is inhibited by rapamycin, which also rescues lymphomagenesis in Atm-deficient mice. Sirolimus 93-102 ataxia telangiectasia mutated Mus musculus 142-145 19364503-4 2009 Here, we show that inhibition of mTOR signaling with its specific inhibitor, rapamycin, suppresses normal thymocyte DNA synthesis by downregulating 4EBP1, but not S6K, and that 4EBP1 phosphorylation and cyclin D1 expression are coordinately increased in Atm-/- thymocytes. Sirolimus 77-86 ataxia telangiectasia mutated Mus musculus 254-257 19364503-5 2009 Administration of rapamycin to Atm-/- mice attenuates elevated phospho-4EBP1, c-Myc and cyclin D1 in their thymocytes, and delays thymic lymphoma development. Sirolimus 18-27 ataxia telangiectasia mutated Mus musculus 31-34