PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25116684-0	2014	Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways.	Sirolimus	0-9	hepatocyte growth factor	Homo sapiens	31-34	
27840956-6	2017	HGF-stimulated cell motility of ARMS cell lines was inhibited by U0126 (ERK1/2 inhibitor) but was only partially inhibited by PD98059 (ERK1 inhibitor) or rapamycin (mTOR inhibitor) as observed in wound-healing and migration assays.	Sirolimus	154-163	hepatocyte growth factor	Homo sapiens	0-3	
25116684-4	2014	The purpose of our study was to investigate the potential effects of rapamycin on HGF-induced LECs and the underlying mechanisms by which rapamycin exerted its actions.	Sirolimus	69-78	hepatocyte growth factor	Homo sapiens	82-85	
25116684-4	2014	The purpose of our study was to investigate the potential effects of rapamycin on HGF-induced LECs and the underlying mechanisms by which rapamycin exerted its actions.	Sirolimus	138-147	hepatocyte growth factor	Homo sapiens	82-85	
25116684-6	2014	Further investigation of the underlying mechanism using siRNA transfection revealed that rapamycin could promote apoptosis of LECs via inhibiting HGF-induced phosphorylation of AKT/mTOR, ERK and JAK2/STAT3 signaling molecules.	Sirolimus	89-98	hepatocyte growth factor	Homo sapiens	146-149	
25116684-8	2014	Together, these findings suggested that rapamycin-induced apoptosis in HGF-stimulated LECs is accompanied by inhibition of AKT/mTOR, ERK and JAK2/STAT3 pathways, which supports its use to inhibit PCO in preclinical studies and provides theoretical foundation for future possible practice.	Sirolimus	40-49	hepatocyte growth factor	Homo sapiens	71-74	
23209838-5	2012	Pretreatment with PI3K inhibitor (Ly294002), Akt inhibitor, or mTORC1 inhibitor (rapamycin) blocked the HGF-induced VEGF-A production.	Sirolimus	81-90	hepatocyte growth factor	Homo sapiens	104-107	
17466941-5	2007	Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), suppressed leucine-induced activation of p70 S6 kinase and 4E-BP1 and negated the stimulatory effect of leucine on HGF production.	Sirolimus	0-9	hepatocyte growth factor	Homo sapiens	180-183	
17202813-2	2007	The effect of rapamycin on proliferation and cellular function was studied in hepatocytes stimulated by hepatocyte growth factor (HGF) or transforming growth factor-alpha (TGFalpha).	Sirolimus	14-23	hepatocyte growth factor	Homo sapiens	104-128	
17202813-5	2007	The HGF- or TGFalpha-induced increase in DNA synthesis and in albumin or fibrinogen concentrations was suppressed by the addition of rapamycin, as well as wortmannin, a phosphatidylinositol-3 kinase inhibitor.	Sirolimus	133-142	hepatocyte growth factor	Homo sapiens	4-8	
30242894-7	2019	Our study demonstrated that rapamycin decreased the protective effects of HGF on the endothelium by decreasing tight junction protein occludin expression and cell proliferation, and raising lipopolysaccharide (LPS)-induced endothelial permeability, endothelial cell injury factors ET-1 and vWF.	Sirolimus	28-37	hepatocyte growth factor	Homo sapiens	74-77