PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27847820-6 2016 Furthermore, we demonstrated that neural differentiation in these iPS cells was accompanied by autophagy and that rapamycin promoted autophagy through degradation of mutant ATXN3 proteins in neurally differentiated spinocerebellar ataxia-3 human induced pluripotent stem cells (p < 0.05). Sirolimus 114-123 ataxin 3 Homo sapiens 173-178 18418060-3 2008 Recently it was proposed that rapamycin and its derivatives enhance the clearance (and/or reduce the accumulation) of mutant intracellular proteins causing proteinopathies such as tau, alpha-synuclein, ataxin-3, and full-length or fragments of huntingtin containing a polyglutamine (polyQ) expansion, by upregulating macroautophagy. Sirolimus 30-39 ataxin 3 Homo sapiens 202-210