PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18776922-3	2008	Here, we show that rapamycin treatment stimulated androgen receptor (AR) transcriptional activity, whereas suppression of AR activity with the antiandrogen bicalutamide sensitized androgen-dependent, as well as AR-sensitive androgen-independent prostate cancer cells, to growth inhibition by rapamycin.	Sirolimus	19-28	androgen receptor	Homo sapiens	50-67	
31966605-8	2017	Autophagy promotion by rapamycin enhanced apoptosis in bladder cancer cells, especially in AR-positive UM-UC-3 cells when AR signaling was inhibited by bicalutamide.	Sirolimus	23-32	androgen receptor	Homo sapiens	91-93	
31966605-8	2017	Autophagy promotion by rapamycin enhanced apoptosis in bladder cancer cells, especially in AR-positive UM-UC-3 cells when AR signaling was inhibited by bicalutamide.	Sirolimus	23-32	androgen receptor	Homo sapiens	122-124	
27484210-2	2016	We further hypothesized that co-treatment of CDK inhibitors with rapamycin, an mTOR inhibitor, would be an effective combinatory strategy for the inhibition of prostate cancer regard to androgen receptor (AR) status due to inhibition of proliferative pathway, PI3K/AKT/mTOR, and induction of cell death mechanisms.	Sirolimus	65-74	androgen receptor	Homo sapiens	186-203	
27484210-2	2016	We further hypothesized that co-treatment of CDK inhibitors with rapamycin, an mTOR inhibitor, would be an effective combinatory strategy for the inhibition of prostate cancer regard to androgen receptor (AR) status due to inhibition of proliferative pathway, PI3K/AKT/mTOR, and induction of cell death mechanisms.	Sirolimus	65-74	androgen receptor	Homo sapiens	205-207	
27484210-4	2016	Co-treatment of rapamycin modulated CDK inhibitors-induced cytotoxicity and apoptosis that CDK inhibitors were more potent to induce cell death in AR (+) LNCaP cells than AR (-) DU145 cells.	Sirolimus	16-25	androgen receptor	Homo sapiens	147-149	
27484210-4	2016	Co-treatment of rapamycin modulated CDK inhibitors-induced cytotoxicity and apoptosis that CDK inhibitors were more potent to induce cell death in AR (+) LNCaP cells than AR (-) DU145 cells.	Sirolimus	16-25	androgen receptor	Homo sapiens	171-173	
27557496-7	2016	Rapamycin enhanced the AR protein level without altering phosphoAR-Ser81 and CYP17A1.	Sirolimus	0-9	androgen receptor	Homo sapiens	23-25	
26371515-5	2015	We further showed that Prp8 could regulate NES(AR) function using short hairpin RNA knockdown of Prp8 coupled with a rapamycin export assay in mammalian cells and knockdown of Prp8 could induce nuclear accumulation of GFP-tagged AR in PC3 cells.	Sirolimus	117-126	androgen receptor	Homo sapiens	47-49	
24861463-10	2014	Mechanistically, regulation of G6PD via AR in both hormone-sensitive and castration-resistant models of prostate cancer was abolished following rapamycin treatment, indicating that AR increased flux through the pentose phosphate pathway by the mammalian target of rapamycin (mTOR)-mediated upregulation of G6PD.	Sirolimus	144-153	androgen receptor	Homo sapiens	181-183	
28507054-8	2017	In contrast, rapamycin was able to decrease the androgen-mediated expression of SLC1A4 and SLC1A5 independent of PTEN status, indicating that mTOR complex 1 (mTORC1) was needed for maximal AR-mediated glutamine uptake and prostate cancer cell growth.	Sirolimus	13-22	androgen receptor	Homo sapiens	189-191	
18776922-3	2008	Here, we show that rapamycin treatment stimulated androgen receptor (AR) transcriptional activity, whereas suppression of AR activity with the antiandrogen bicalutamide sensitized androgen-dependent, as well as AR-sensitive androgen-independent prostate cancer cells, to growth inhibition by rapamycin.	Sirolimus	19-28	androgen receptor	Homo sapiens	69-71	
18776922-7	2008	The effect of rapamycin on AR transcriptional activity was mediated by the phosphorylation of the serine/threonine kinase Akt, which also partially mediated apoptosis induced by rapamycin and bicalutamide.	Sirolimus	14-23	androgen receptor	Homo sapiens	27-29	
18776922-7	2008	The effect of rapamycin on AR transcriptional activity was mediated by the phosphorylation of the serine/threonine kinase Akt, which also partially mediated apoptosis induced by rapamycin and bicalutamide.	Sirolimus	178-187	androgen receptor	Homo sapiens	27-29