PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33428109-9 2021 The mTOR inhibitor rapamycin mitigated TGF-beta-induced expression of p21, p16, and DNA damage foci and improved replicative potential of preadipocytes, supporting the cell-specific response to this cytokine. Sirolimus 19-28 transforming growth factor alpha Homo sapiens 39-47 33614662-7 2021 Rapamycin mitigated these effects by activation of the classical TGF-beta/Smad signaling pathway and increasing the transcriptional activity of MAPK/AP-1. Sirolimus 0-9 transforming growth factor alpha Homo sapiens 65-73 32736702-3 2020 In the present study, using cultured ARPE-19 cells, we determined that TGF-beta initiates a signaling pathway through extracellular signal-regulated kinase (ERK)-mammalian target of rapamycin complex 1 (mTORC1) that stimulates trans-differentiation and fibrosis of retinal pigment epithelium. Sirolimus 182-191 transforming growth factor alpha Homo sapiens 71-79 8980296-6 1997 TGF-alpha stimulation of S6 kinase activity was inhibited in a concentration-dependent manner by rapamycin (IC50 < 0.2 nM) and the specific EGF receptor antagonist PD153035 (IC50 = 20 nM). Sirolimus 97-106 transforming growth factor alpha Homo sapiens 0-9 34563639-2 2021 In the presence of TGFbeta, rapamycin induces G1 cell cycle arrest; however, in the absence of TGFbeta, cells do not arrest in G1 and progress into S-phase where rapamycin is cytotoxic rather than cytostatic. Sirolimus 28-37 transforming growth factor alpha Homo sapiens 19-26 30864227-12 2019 The combination of HMGB1 short interference (si) RNA and the autophagy activator rapamycin protected against podocyte apoptosis and EMT progression by inhibiting the AKT/mTOR and TGF-beta/smad signaling pathway, respectively. Sirolimus 81-90 transforming growth factor alpha Homo sapiens 179-187 17202813-5 2007 The HGF- or TGFalpha-induced increase in DNA synthesis and in albumin or fibrinogen concentrations was suppressed by the addition of rapamycin, as well as wortmannin, a phosphatidylinositol-3 kinase inhibitor. Sirolimus 133-142 transforming growth factor alpha Homo sapiens 12-20 34236783-12 2022 However, rapamycin or paclitaxel concentrations >=1 mug/mL could significantly reduce the levels of anti-inflammatory cytokines IL-35 and transforming growth factor beta (TGF-beta) (P<0.05 or P<0.01), which decreased with the increase of drug concentration. Sirolimus 9-18 transforming growth factor alpha Homo sapiens 171-179 34236783-14 2022 However, rapamycin or paclitaxel combined with anti- IL-10 or anti-TGF-beta can significantly enhance foam cell proliferation (P<0.01). Sirolimus 9-18 transforming growth factor alpha Homo sapiens 67-75