PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29911787-1 2017 This study was designed to investigate effects of pargyline on histone methylation in the promoter and enhancer regions and transcription of cytochrome P450 3A4/3A7 (CYP3A4/3A7) gene. Pargyline 50-59 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 166-176 29911787-11 2017 The level of CYP3A7 was markedly enhanced in human primary fetal liver cells by treatment with 1.2, 2.4 mmol L(-1) of pargyline (P < 0.05, P < 0.01) and the levels of CYP3A4/3A7 were remarkably enhanced by treatment with 3 mmol L(-1) of pargyline in HepG2 cells (P < 0.001) compared with solvent control. Pargyline 118-127 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 173-179 29911787-14 2017 In conclusion, the enriched H3K4me2 in the promoter and enhancer regions was induced by pargyline with HNF4A or GR binding site in CYP3A4/3A7 gene to activate the corresponding genes. Pargyline 88-97 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 131-137