PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8147263-3	1993	Addition of an MAO inhibitor such as pargyline to tissue preparations can increase the HNMT activity assayed --presumably as a result of inhibition of N tau-methylhistamine metabolism by MAO.	Pargyline	37-46	histamine N-methyltransferase	Homo sapiens	87-91	
8147263-7	1993	The activity of the purified HNMT was increased approximately 50% in the presence of pargyline.	Pargyline	85-94	histamine N-methyltransferase	Homo sapiens	29-33	
8147263-8	1993	However, enzyme kinetic experiments showed that pargyline, like many other amines, was a competitive inhibitor of HNMT.	Pargyline	48-57	histamine N-methyltransferase	Homo sapiens	114-118	
8147263-12	1993	When the concentration of the cosubstrate for the reaction, S-adenosyl-L-methionine, was varied in the presence of variable concentrations of pargyline, inhibition of HNMT by pargyline was noncompetitive with regard to the methyl donor, with Kii and Kis values of 1.23 and 0.95 mM, respectively.	Pargyline	175-184	histamine N-methyltransferase	Homo sapiens	167-171	
8147263-13	1993	Finally, several amine compounds related structurally to pargyline were also found to be inhibitors of HNMT.	Pargyline	57-66	histamine N-methyltransferase	Homo sapiens	103-107