PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24555085-9 2013 CYP3A5 mRNA induction by five different glucocorticoids was attenuated by inhibiting the glucocorticoid receptor using ketoconazole, and for beclomethasone dipropionate, using siRNA-mediated knock-down of the glucocorticoid receptor. Beclomethasone 141-168 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 0-6 25825214-0 2015 Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone. Beclomethasone 73-87 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 10-16 23512537-6 2013 CYP3A4 and CYP3A5 metabolized BDP via hydroxylation ([M4] and [M6]) and dehydrogenation ([M5]) at similar rates; CYP3A7 did not metabolize BDP. Beclomethasone 30-33 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 11-17 23512537-11 2013 These studies show that CYP3A4 and CYP3A5 metabolize BDP to inactive metabolites and suggest that differences in the expression or function of these enzymes in the lung and/or liver could influence BDP disposition in humans. Beclomethasone 53-56 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 35-41