PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28178994-11	2017	RESULTS: Doxycycline decreased plasma lysophosphatidate concentrations, delayed tumor growth and decreased the concentrations of several cytokines/chemokines (IL-1beta, IL-6, IL-9, CCL2, CCL11, CXCL1, CXCL2, CXCL9, G-CSF, LIF, VEGF) in the tumor.	Doxycycline	9-20	C-C motif chemokine ligand 2	Homo sapiens	181-185	
31029854-10	2019	Doxycycline-induced tetNGN3-HIEs secreted serotonin, monocyte chemoattractant protein-1, glucose-dependent insulinotropic peptide, peptide YY, and ghrelin in response to norepinephrine and rotavirus infection, further supporting the presence of multiple EEC types.	Doxycycline	0-11	C-C motif chemokine ligand 2	Homo sapiens	53-87	
27486749-3	2016	This work was completed by an analysis of the effects of cyclosporine A (CsA), dexamethasone (Dex) and doxycycline (Dox) on HO-induced CCL2 and NFAT5 induction.	Doxycycline	103-114	C-C motif chemokine ligand 2	Homo sapiens	135-139	
16809218-0	2006	Doxycycline decreases monocyte chemoattractant protein-1 in human lung epithelial cells.	Doxycycline	0-11	C-C motif chemokine ligand 2	Homo sapiens	22-56	
16809218-4	2006	The authors hypothesized that doxycycline exerts its anti-inflammatory effects, in part, by reducing MCP-1 production.	Doxycycline	30-41	C-C motif chemokine ligand 2	Homo sapiens	101-106	
16809218-6	2006	In stimulated cells doxycycline decreased MCP-1 production by 95% and in monocyte chemotaxis assays migration decreased by 55%.	Doxycycline	20-31	C-C motif chemokine ligand 2	Homo sapiens	42-47	
16809218-7	2006	However, doxycycline did decrease expression of MCP-1 mRNA and did not effect its stability.	Doxycycline	9-20	C-C motif chemokine ligand 2	Homo sapiens	48-53	
16809218-8	2006	These data demonstrate that doxycycline modulates MCP-1 production and suggest that doxycycline may provide a new anti-inflammatory therapy for chronic lung diseases.	Doxycycline	28-39	C-C motif chemokine ligand 2	Homo sapiens	50-55	
27486749-3	2016	This work was completed by an analysis of the effects of cyclosporine A (CsA), dexamethasone (Dex) and doxycycline (Dox) on HO-induced CCL2 and NFAT5 induction.	Doxycycline	116-119	C-C motif chemokine ligand 2	Homo sapiens	135-139	
21771657-3	2011	In this paper, we discuss the evidence that doxycycline and related non-antibiotic chemically modified tetracyclines (e.g., CMT-3) can effectively reduce cytokine (TNF-alpha, IL-6, and MCP-1) production by human mononuclear inflammatory cells when stimulated either by endotoxin (LPS) or by a complex of C-reactive protein/oxidized LDL cholesterol relevant to the pathogenesis of periodontal disease and ASCVD, respectively.	Doxycycline	44-55	C-C motif chemokine ligand 2	Homo sapiens	185-190