PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12498775-0 2002 Mechanisms leading to sustained reversion of beta-thalassemia in mice by doxycycline-controlled Epo delivery from muscles. Doxycycline 73-84 erythropoietin Mus musculus 96-99 20924361-3 2011 Primary DRG neurons in culture infected with vHrtEPO express and release EPO in response to exposure to doxycycline (DOX). Doxycycline 104-115 erythropoietin Mus musculus 49-52 20924361-3 2011 Primary DRG neurons in culture infected with vHrtEPO express and release EPO in response to exposure to doxycycline (DOX). Doxycycline 117-120 erythropoietin Mus musculus 49-52 20924361-4 2011 Animals infected with vHrtEPO by footpad inoculation demonstrated regulated expression of EPO in DRG under the control of DOX administered by gavage. Doxycycline 122-125 erythropoietin Mus musculus 26-29 22089494-3 2012 EPO expression from the vector was tightly controlled by administration of doxycycline (DOX) in vitro. Doxycycline 75-86 erythropoietin Mus musculus 0-3 22089494-3 2012 EPO expression from the vector was tightly controlled by administration of doxycycline (DOX) in vitro. Doxycycline 88-91 erythropoietin Mus musculus 0-3 22089494-4 2012 One month after inoculation of the vector to transduce dorsal root ganglion (DRG) in vivo, administration of DOX-containing chow-induced expression of EPO. Doxycycline 109-112 erythropoietin Mus musculus 151-154 20499015-10 2010 Doxycycline administration was efficient in controlling Epo secretion in both groups. Doxycycline 0-11 erythropoietin Mus musculus 56-59 15468192-5 2005 In the presence of doxycycline, a single injection of 10 microg plasmid encoding inducible murine erythropoietin formulated with PE6400 significantly increased the hematocrit, whereas the same amount of DNA in the absence of PE6400 had no effect. Doxycycline 19-30 erythropoietin Mus musculus 98-112 9716577-0 1998 Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector. Doxycycline 38-49 erythropoietin Mus musculus 11-25 12161181-0 2002 Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts. Doxycycline 10-21 erythropoietin Mus musculus 45-59 12161181-2 2002 We investigated doxycycline-based regulation of gene expression to modulate the secretion of erythropoietin (EPO) from encapsulated myoblasts in a mouse model. Doxycycline 16-27 erythropoietin Mus musculus 93-107 12161181-2 2002 We investigated doxycycline-based regulation of gene expression to modulate the secretion of erythropoietin (EPO) from encapsulated myoblasts in a mouse model. Doxycycline 16-27 erythropoietin Mus musculus 109-112 10048390-0 1999 Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells. Doxycycline 39-50 erythropoietin Mus musculus 11-25 10048390-3 1999 We generated populations of immortalized murine NIH 3T3 fibroblasts that secrete mouse erythropoietin (Epo) in response to stimulation by doxycycline or mifepristone. Doxycycline 138-149 erythropoietin Mus musculus 87-101 10048390-3 1999 We generated populations of immortalized murine NIH 3T3 fibroblasts that secrete mouse erythropoietin (Epo) in response to stimulation by doxycycline or mifepristone. Doxycycline 138-149 erythropoietin Mus musculus 103-106 10048390-5 1999 Animals receiving doxycycline or mifepristone showed stable polyhemia and increased serum Epo concentrations over a 6-month observation period, whereas animals not receiving the inducer drug had normal hematocrits. Doxycycline 18-29 erythropoietin Mus musculus 90-93 10048390-6 1999 Epo secretion could be switched on and off, depending on the presence of doxycycline in the drinking water. Doxycycline 73-84 erythropoietin Mus musculus 0-3 9716577-4 1998 Because this method is potentially applicable clinically, we constructed an AAV vector in which the expression of the mouse erythropoietin (Epo) cDNA is modulated in response to doxycycline. Doxycycline 178-189 erythropoietin Mus musculus 124-138 9716577-4 1998 Because this method is potentially applicable clinically, we constructed an AAV vector in which the expression of the mouse erythropoietin (Epo) cDNA is modulated in response to doxycycline. Doxycycline 178-189 erythropoietin Mus musculus 140-143 9716577-6 1998 We observed that hematocrit and serum Epo concentrations could be modulated over a 29-week period in response to the presence or absence of doxycycline in the drinking water of these animals. Doxycycline 140-151 erythropoietin Mus musculus 38-41 9055857-0 1997 Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Doxycycline 49-60 erythropoietin Mus musculus 21-35 9055857-4 1997 After transplantation of transduced cells into mouse skeletal muscles, Epo secretion could be iteratively switched on and off over a five-month period, depending on the presence or the absence of doxycycline in the drinking water. Doxycycline 196-207 erythropoietin Mus musculus 71-74 29051279-6 2018 We also generated inducible EPO-mediated secondary erythrocytosis models using Alb-Cre, Rosa26-loxP-stop-loxP-rtTA, and doxycycline inducible EPAS1-double point mutant (DPM) alleles (Alb-Cre;DPM mice). Doxycycline 120-131 erythropoietin Mus musculus 28-31