PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11327259-6	2001	In addition, treatment with 10 microg/ml doxycycline resulted in 2.2-fold upregulation of transforming growth factor (TGF-beta3) and a significant decrease of interleukin 1alpha (IL-1alpha), IL-1beta, and IL-6 mRNA.	Doxycycline	41-52	interleukin 1 alpha	Homo sapiens	159-177	
11327259-6	2001	In addition, treatment with 10 microg/ml doxycycline resulted in 2.2-fold upregulation of transforming growth factor (TGF-beta3) and a significant decrease of interleukin 1alpha (IL-1alpha), IL-1beta, and IL-6 mRNA.	Doxycycline	41-52	interleukin 1 alpha	Homo sapiens	179-188	
10937565-0	2000	Doxycycline inhibition of interleukin-1 in the corneal epithelium.	Doxycycline	0-11	interleukin 1 alpha	Homo sapiens	26-39	
11078862-0	2000	Doxycycline inhibition of interleukin-1 in the corneal epithelium	Doxycycline	0-11	interleukin 1 alpha	Homo sapiens	26-39	
32241426-6	2020	Dox:CS/CMCS-NPs effectively down-regulated both gene and protein levels of NLRP3 inflammasome and IL-1beta in HGFs.	Doxycycline	0-3	interleukin 1 alpha	Homo sapiens	98-106	
34988139-10	2021	In addition, SGDL granule + doxycycline effectively inhibited IBV replication and stopped IBV propagation from the trachea to the lung; modulated the mRNA expressions of IL-1beta, IL-6, TNF-alpha, and IFN-gamma; and extenuated the histopathology lesions in trachea and lung.	Doxycycline	28-39	interleukin 1 alpha	Homo sapiens	170-178	
3325909-5	1987	Spiramycin and doxycycline using 100 micrograms/ml increased extracellular IL-1 while cell-associated was decreased.	Doxycycline	15-26	interleukin 1 alpha	Homo sapiens	75-79	
19813262-0	2010	Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses.	Doxycycline	81-92	interleukin 1 alpha	Homo sapiens	96-105	
29894913-4	2018	The goal of the current study was to engineer cartilage and bone constructs with the ability to inhibit aberrant inflammatory processes caused by the cytokine interleukin-1 (IL-1), through scaffold-mediated delivery of lentiviral particles containing a doxycycline-inducible IL-1 receptor antagonist (IL-1Ra) transgene on anatomically-shaped CDM constructs.	Doxycycline	253-264	interleukin 1 alpha	Homo sapiens	174-178	
29874670-1	2018	AIMS: The purpose of this paper was to determine the lacrimal concentration of IL-1alpha and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline.	Doxycycline	195-206	interleukin 1 alpha	Homo sapiens	79-88	
29874670-6	2018	There was a strong clinical correlation of higher baseline IL-1alpha tear levels between patients who responded to doxycycline therapy and those who failed (p = 0.043).	Doxycycline	115-126	interleukin 1 alpha	Homo sapiens	59-68	
18094719-5	2008	Microarray analysis of doxycycline-induced and doxycycline-uninduced cells revealed an upregulation by ETS2 of cytokines (for example, interleukin 1 and CSF2) and transcription factors (for example, TAL1), which are key regulators of megakaryocytic differentiation.	Doxycycline	23-34	interleukin 1 alpha	Homo sapiens	135-148	
18094719-5	2008	Microarray analysis of doxycycline-induced and doxycycline-uninduced cells revealed an upregulation by ETS2 of cytokines (for example, interleukin 1 and CSF2) and transcription factors (for example, TAL1), which are key regulators of megakaryocytic differentiation.	Doxycycline	47-58	interleukin 1 alpha	Homo sapiens	135-148