PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31861307-8 2019 However, stratified analyses showed a significant inverse correlation between changes in PSA and changes in selenium in men below the median age (p = 0.048), never-smokers (p = 0.031), men carrying the GPX1 rs1050450 T allele (CT, p = 0.022 and TT, p = 0.011), dietary intakes above the recommended daily intake (RDI) for zinc (p < 0.05), and below the RDI for vitamin B12 (p < 0.001). Selenium 108-116 kallikrein related peptidase 3 Homo sapiens 89-92 27406859-6 2017 In separate post-hoc analyses, we observed that median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium and C20:5 n-3 fatty acid (p = 0.003). Selenium 141-149 kallikrein related peptidase 3 Homo sapiens 55-58 27406859-6 2017 In separate post-hoc analyses, we observed that median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium and C20:5 n-3 fatty acid (p = 0.003). Selenium 259-267 kallikrein related peptidase 3 Homo sapiens 55-58 27406859-8 2017 CONCLUSIONS: Three week nutritional interventions with tomato-products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer. Selenium 100-108 kallikrein related peptidase 3 Homo sapiens 135-138 20647337-8 2010 In the highest quartile of baseline selenium, men supplemented with 800 microg selenium showed statistically significantly higher PSA velocity as compared with placebo (P = 0.018). Selenium 79-87 kallikrein related peptidase 3 Homo sapiens 130-133 24012146-0 2013 Use of selenium-silymarin mix reduces lower urinary tract symptoms and prostate specific antigen in men. Selenium 7-15 kallikrein related peptidase 3 Homo sapiens 71-96 24012146-5 2013 There was a significant reduction in PSA in the selenium-silymarin group but no effect on blood testosterone level. Selenium 48-56 kallikrein related peptidase 3 Homo sapiens 37-40 21419321-4 2011 The hypothesis was confirmed, in that selenium supplementation raised activities for erythrocyte and plasma glutathione peroxidase as well as lowered values for plasma prostate-specific antigen. Selenium 38-46 kallikrein related peptidase 3 Homo sapiens 168-193 20647337-10 2010 On the contrary, supplementation with high-dose selenium was observed to be a risk factor for increased PSA velocity in men with high baseline plasma selenium concentrations. Selenium 48-56 kallikrein related peptidase 3 Homo sapiens 104-107 20647337-10 2010 On the contrary, supplementation with high-dose selenium was observed to be a risk factor for increased PSA velocity in men with high baseline plasma selenium concentrations. Selenium 150-158 kallikrein related peptidase 3 Homo sapiens 104-107 19943972-6 2009 RESULTS: Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Selenium 9-17 kallikrein related peptidase 3 Homo sapiens 130-155 16637076-0 2006 Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). Selenium 15-23 kallikrein related peptidase 3 Homo sapiens 150-181 17572195-11 2007 CONCLUSIONS: The results of our study have shown that a decrease in the PSA level while taking a selenium, vitamin E, and soy isoflavonoids supplement predicts for a significantly lower risk of PCa in future biopsies. Selenium 97-105 kallikrein related peptidase 3 Homo sapiens 72-75 18617077-10 2008 CONCLUSIONS: When prospective SES-related confounding factors are matched across comparison communities, PSA IDM interventions can be shown to promote IDM. Selenium 30-33 kallikrein related peptidase 3 Homo sapiens 105-108 15141018-0 2004 Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription. Selenium 7-15 kallikrein related peptidase 3 Homo sapiens 37-62 16648561-3 2006 Previous studies showed a novel mechanism of selenium anticancer action in which selenium markedly reduces androgen signaling and androgen receptor (AR)-mediated gene expression, including prostate-specific antigen (PSA), in human prostate cancer cells. Selenium 45-53 kallikrein related peptidase 3 Homo sapiens 189-221 16648561-3 2006 Previous studies showed a novel mechanism of selenium anticancer action in which selenium markedly reduces androgen signaling and androgen receptor (AR)-mediated gene expression, including prostate-specific antigen (PSA), in human prostate cancer cells. Selenium 81-89 kallikrein related peptidase 3 Homo sapiens 189-221 16648561-9 2006 Chromatin immunoprecipitation analyses showed that DHT increased the recruitment of AR and coactivators, such as SRC-1 and TIF-2, to the promoter of the PSA gene, and that recruitment was greatly diminished in the presence of 5 micromol/L selenium. Selenium 239-247 kallikrein related peptidase 3 Homo sapiens 153-156 16648561-10 2006 On the other hand, selenium enhanced the recruitment of corepressors, such as SMRT, to the promoter of the PSA gene. Selenium 19-27 kallikrein related peptidase 3 Homo sapiens 107-110 15141018-3 2004 A better understanding of the effects of selenium metabolites on the kinetics of PSA turnover and secretion in prostate cancer cells treated with selenium at concentrations which are achievable physiologically will be important for interpreting the results of these trials. Selenium 41-49 kallikrein related peptidase 3 Homo sapiens 81-84 15141018-3 2004 A better understanding of the effects of selenium metabolites on the kinetics of PSA turnover and secretion in prostate cancer cells treated with selenium at concentrations which are achievable physiologically will be important for interpreting the results of these trials. Selenium 146-154 kallikrein related peptidase 3 Homo sapiens 81-84 15141018-4 2004 This study addresses whether the putative active anticancer selenium metabolite methylselenol or its precursor methylseleninic acid (MSeA) specifically inhibits PSA expression in the androgen-responsive LNCaP prostate cancer cell model. Selenium 60-68 kallikrein related peptidase 3 Homo sapiens 161-164 14713754-5 2004 The available data suggest a beneficial effect for men with low baseline serum or toenail selenium levels, without preexisting tumors, with serum prostate specific antigen less than 4 ng/ml and in current or former smokers. Selenium 90-98 kallikrein related peptidase 3 Homo sapiens 146-171 14729601-0 2004 Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Selenium 58-66 kallikrein related peptidase 3 Homo sapiens 0-25 12539231-12 2003 These data suggest that changes in serum PSA levels in individual patients during selenium supplementation is not an effect specific for PSA secretion, but rather may be a useful indicator for changes in disease progression in individual patients. Selenium 82-90 kallikrein related peptidase 3 Homo sapiens 41-44