PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28360100-5	2017	Major food-associated TFAs such as elaidic acid (EA), linoelaidic acid, and trans-vaccenic acid, but not their corresponding cis isomers, dramatically enhanced extracellular ATP-induced apoptosis, accompanied by elevated activation of the ASK1-p38 pathway in a macrophage-like cell line, RAW264.7.	Trans Fatty Acids	22-26	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	239-243	
28360100-0	2017	trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.	Trans Fatty Acids	0-17	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	86-122	
28360100-0	2017	trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.	Trans Fatty Acids	0-17	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	124-128	
28360100-4	2017	Here we have shown that TFAs potentiate activation of apoptosis signal-regulating kinase 1 (ASK1) induced by extracellular ATP, a damage-associated molecular pattern leaked from injured cells.	Trans Fatty Acids	24-28	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	54-90	
28360100-4	2017	Here we have shown that TFAs potentiate activation of apoptosis signal-regulating kinase 1 (ASK1) induced by extracellular ATP, a damage-associated molecular pattern leaked from injured cells.	Trans Fatty Acids	24-28	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	92-96	
28360100-9	2017	These results demonstrate that TFAs promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of TFA-induced atherosclerosis.	Trans Fatty Acids	31-35	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	93-97	
28360100-9	2017	These results demonstrate that TFAs promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of TFA-induced atherosclerosis.	Trans Fatty Acids	31-34	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	93-97	
33990641-0	2021	trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway.	Trans Fatty Acids	0-17	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	125-129	
33990641-4	2021	We previously reported that TFAs promote apoptosis induced by doxorubicin (Dox), a double strand break (DSB)-inducing agent, via a non-canonical apoptotic pathway independent of tumor suppressor p53 and apoptosis signal-regulating kinase (ASK1), a reactive oxygen species (ROS)-responsive kinase.	Trans Fatty Acids	28-32	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	239-243	
33990641-7	2021	These results demonstrate that in response to CDDP ICLs, TFAs promote p53-dependent apoptosis through the enhancement of the Nox-RIP1-ASK1-MAPK pathway activation, providing insight into the diverse pathogenetic mechanisms of TFAs according to the types of DNA damage.	Trans Fatty Acids	57-61	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	134-138	
31582606-8	2019	We also found that trans-fatty acids (TFAs) enhance ROS-dependent ASK1 activation induced by extracellular ATP, a damage-associated molecular pattern (DAMP), and thereby promotes apoptosis, which possibly contributes to the pathogenesis of TFA-related diseases including atherosclerosis.	Trans Fatty Acids	19-36	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	66-70	
31582606-8	2019	We also found that trans-fatty acids (TFAs) enhance ROS-dependent ASK1 activation induced by extracellular ATP, a damage-associated molecular pattern (DAMP), and thereby promotes apoptosis, which possibly contributes to the pathogenesis of TFA-related diseases including atherosclerosis.	Trans Fatty Acids	38-42	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	66-70	
31582606-8	2019	We also found that trans-fatty acids (TFAs) enhance ROS-dependent ASK1 activation induced by extracellular ATP, a damage-associated molecular pattern (DAMP), and thereby promotes apoptosis, which possibly contributes to the pathogenesis of TFA-related diseases including atherosclerosis.	Trans Fatty Acids	38-41	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	66-70