PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31831259-0 2020 GdCl3 attenuates the glomerular sclerosis of streptozotocin (STZ) induced diabetic rats via inhibiting TGF-beta/Smads signal pathway. Gadolinium 0-5 transforming growth factor, beta 1 Rattus norvegicus 103-111 31831259-3 2020 In this study, we found that GdCl3 which was an agonist of Calcium-sensing receptor (CaSR) could repress the activation of TGF-beta/Smads signal pathway induced by TGF-beta1 or high glucose and then alleviated the accumulation of extracellular matrix (ECM) in mesangial cells and the kidney of type1 diabetic rats. Gadolinium 29-34 transforming growth factor, beta 1 Rattus norvegicus 123-131 31831259-3 2020 In this study, we found that GdCl3 which was an agonist of Calcium-sensing receptor (CaSR) could repress the activation of TGF-beta/Smads signal pathway induced by TGF-beta1 or high glucose and then alleviated the accumulation of extracellular matrix (ECM) in mesangial cells and the kidney of type1 diabetic rats. Gadolinium 29-34 transforming growth factor, beta 1 Rattus norvegicus 164-173 31831259-4 2020 Further study indicated that GdCl3 could induce the binding of CaSR and TbetaR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TbetaR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-beta1, so that the activation of its downstream factors such as Smad2 and Smad3 were blocked, finally, ECM expression in mesangial cells were inhibited. Gadolinium 29-34 transforming growth factor, beta 1 Rattus norvegicus 279-288 31831259-5 2020 We concluded that GdCl3 could alleviate the accumulation of ECM in mesangial cells via antagonizing TGF-beta/Smads signal pathway in diabetes mellitus. Gadolinium 18-23 transforming growth factor, beta 1 Rattus norvegicus 100-108