PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31831259-0	2020	GdCl3 attenuates the glomerular sclerosis of streptozotocin (STZ) induced diabetic rats via inhibiting TGF-beta/Smads signal pathway.	Gadolinium	0-5	transforming growth factor, beta 1	Rattus norvegicus	103-111	
31831259-3	2020	In this study, we found that GdCl3 which was an agonist of Calcium-sensing receptor (CaSR) could repress the activation of TGF-beta/Smads signal pathway induced by TGF-beta1 or high glucose and then alleviated the accumulation of extracellular matrix (ECM) in mesangial cells and the kidney of type1 diabetic rats.	Gadolinium	29-34	transforming growth factor, beta 1	Rattus norvegicus	123-131	
31831259-3	2020	In this study, we found that GdCl3 which was an agonist of Calcium-sensing receptor (CaSR) could repress the activation of TGF-beta/Smads signal pathway induced by TGF-beta1 or high glucose and then alleviated the accumulation of extracellular matrix (ECM) in mesangial cells and the kidney of type1 diabetic rats.	Gadolinium	29-34	transforming growth factor, beta 1	Rattus norvegicus	164-173	
31831259-4	2020	Further study indicated that GdCl3 could induce the binding of CaSR and TbetaR II and then both of these two receptors translocated from cell membrane to cytoplasm, in this case, TbetaR II on the cell membrane was decreased and then desensitized to the stimulation of its ligand TGF-beta1, so that the activation of its downstream factors such as Smad2 and Smad3 were blocked, finally, ECM expression in mesangial cells were inhibited.	Gadolinium	29-34	transforming growth factor, beta 1	Rattus norvegicus	279-288	
31831259-5	2020	We concluded that GdCl3 could alleviate the accumulation of ECM in mesangial cells via antagonizing TGF-beta/Smads signal pathway in diabetes mellitus.	Gadolinium	18-23	transforming growth factor, beta 1	Rattus norvegicus	100-108