PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31941451-1 2020 BACKGROUND: More and more studies demonstrated that genetic variation at C1GALT1 influences Gd-IgA1 level in IgAN. Gadolinium 92-94 immunoglobulin heavy constant alpha 1 Homo sapiens 95-99 31789820-9 2020 The serum level of Gd-IgA1 and intensity of glomerular Gd-IgA1 staining in IgA deposition AAV patients were similar to IgA nephropathy patients. Gadolinium 19-21 immunoglobulin heavy constant alpha 1 Homo sapiens 22-26 31789820-9 2020 The serum level of Gd-IgA1 and intensity of glomerular Gd-IgA1 staining in IgA deposition AAV patients were similar to IgA nephropathy patients. Gadolinium 55-57 immunoglobulin heavy constant alpha 1 Homo sapiens 58-62 31603230-2 2021 The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. Gadolinium 108-110 immunoglobulin heavy constant alpha 1 Homo sapiens 102-106 31603230-2 2021 The purpose of this study was to assess whether ABO blood type is associated with galactose-deficient IgA1 (Gd-IgA1) in the progression of kidney disease in patients with IgAN. Gadolinium 108-110 immunoglobulin heavy constant alpha 1 Homo sapiens 111-115 31603230-3 2021 METHODS: We enrolled 1313 IgAN patients with a median of 44 months follow-up and measured the plasma Gd-IgA1 levels. Gadolinium 101-103 immunoglobulin heavy constant alpha 1 Homo sapiens 104-108 31603230-5 2021 Using the propensity score matching method, 718 IgAN patients with blood type either A or B were selected, and their data were used to assess the association of blood type and Gd-IgA1/serum complement 3 (sC3) with outcomes. Gadolinium 176-178 immunoglobulin heavy constant alpha 1 Homo sapiens 179-183 31603230-7 2021 The Gd-IgA1 levels showed trends similar to the multivariate-adjusted event-free curves for the blood types. Gadolinium 4-6 immunoglobulin heavy constant alpha 1 Homo sapiens 7-11 31603230-8 2021 However, this higher risk of adverse outcomes in type A than in type B patients was no longer significant after the addition of Gd-IgA1/sC3 to the model. Gadolinium 128-130 immunoglobulin heavy constant alpha 1 Homo sapiens 131-135 31603230-9 2021 CONCLUSIONS: IgAN patients with blood type A had a higher risk of adverse outcomes than those with type B, and this risk was associated with Gd-IgA1/sC3. Gadolinium 141-143 immunoglobulin heavy constant alpha 1 Homo sapiens 144-148 31748116-1 2020 Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). Gadolinium 26-28 immunoglobulin heavy constant alpha 1 Homo sapiens 20-24 31748116-1 2020 Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). Gadolinium 26-28 immunoglobulin heavy constant alpha 1 Homo sapiens 29-33 31748116-2 2020 However, the pathogenic mechanisms driving Gd-IgA1 production have not been fully elucidated. Gadolinium 43-45 immunoglobulin heavy constant alpha 1 Homo sapiens 46-50 31748116-3 2020 Innate-immune activation via Toll-like receptor 9 (TLR9) is known to be involved in Gd-IgA1 production. Gadolinium 84-86 immunoglobulin heavy constant alpha 1 Homo sapiens 87-91 31748116-4 2020 A proliferation inducing ligand (APRIL) and IL-6 are also known to enhance Gd-IgA1 synthesis in IgAN. Gadolinium 75-77 immunoglobulin heavy constant alpha 1 Homo sapiens 78-82 31748116-9 2020 However, siRNA knock-down of APRIL completely suppressed overproduction of Gd-IgA1 induced by IL-6. Gadolinium 75-77 immunoglobulin heavy constant alpha 1 Homo sapiens 78-82 31748116-10 2020 Neutralization of IL-6 decreased CpG-oligonucleotide-induced overproduction of Gd-IgA1. Gadolinium 79-81 immunoglobulin heavy constant alpha 1 Homo sapiens 82-86 31748116-11 2020 Furthermore, APRIL and IL-6 pathways each independently mediated TLR9-induced overproduction of Gd-IgA1. Gadolinium 96-98 immunoglobulin heavy constant alpha 1 Homo sapiens 99-103 31748116-13 2020 Hence, APRIL and IL-6 synergistically, as well as independently, enhance synthesis of Gd-IgA1. Gadolinium 86-88 immunoglobulin heavy constant alpha 1 Homo sapiens 89-93 31941451-2 2020 However, whether the expression of beta1, 3-galactosyltransferase (beta1, 3Gal-T) was influenced may provide insights into how Gd-IgA1 levels are controlled in IgAN. Gadolinium 127-129 immunoglobulin heavy constant alpha 1 Homo sapiens 130-134 31941451-4 2020 Total Gd-IgA1 levels in plasma were determined by ELISA and C1GALT1 levels were determined by RT-PCR. Gadolinium 6-8 immunoglobulin heavy constant alpha 1 Homo sapiens 9-13 31941451-7 2020 RESULTS: Gd-IgA1 levels were remarkable higher in IgAN patients compared with healthy control. Gadolinium 9-11 immunoglobulin heavy constant alpha 1 Homo sapiens 12-16 31941451-9 2020 And the mRNA level of C1GALT1 was inversely correlated to Gd-IgA1 levels. Gadolinium 58-60 immunoglobulin heavy constant alpha 1 Homo sapiens 61-65 31941451-15 2020 CONCLUSIONS: We found expression levels of C1GALT1 were remarkably downregulated in IgAN patients and negatively correlated with higher levels of Gd-IgA1. Gadolinium 146-148 immunoglobulin heavy constant alpha 1 Homo sapiens 149-153 32043030-8 2020 Co-localized IgA1 and Gd-IgA1 of both secondary and primary IgAN indicated that they both share the feature of Gd-IgA1 deposits on the glomerular mesangium. Gadolinium 111-113 immunoglobulin heavy constant alpha 1 Homo sapiens 13-17 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 134-136 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 134-136 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 134-136 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-6 2019 Sera and cell-culture supernatants were used for analysis of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies. Gadolinium 61-63 immunoglobulin heavy constant alpha 1 Homo sapiens 64-68 31844808-6 2019 Sera and cell-culture supernatants were used for analysis of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies. Gadolinium 73-75 immunoglobulin heavy constant alpha 1 Homo sapiens 76-80 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 9-13 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-7 2019 Results: IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. Gadolinium 220-222 immunoglobulin heavy constant alpha 1 Homo sapiens 9-13 31844808-9 2019 Levels of Gd-IgA1-specific IgG in sera and supernatants of IgG-producing cells were similar for patients with IgAV-N and IgAN and higher than those for IgAV-woN patients or healthy control subjects. Gadolinium 10-12 immunoglobulin heavy constant alpha 1 Homo sapiens 13-17 31844808-10 2019 Moreover, patients with IgAV-N who had active disease, manifested by hematuria and substantial proteinuria, had higher serum levels of Gd-IgA1-specific IgG autoantibodies than did patients with IgAV-N who had inactive disease. Gadolinium 135-137 immunoglobulin heavy constant alpha 1 Homo sapiens 138-142 31844808-11 2019 Conclusion: Serum levels and cellular production of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies were elevated in patients with IgAV-N, supporting the hypothesis that IgAV-N and IgAN share pathogenic features. Gadolinium 52-54 immunoglobulin heavy constant alpha 1 Homo sapiens 55-59 31844808-11 2019 Conclusion: Serum levels and cellular production of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies were elevated in patients with IgAV-N, supporting the hypothesis that IgAV-N and IgAN share pathogenic features. Gadolinium 64-66 immunoglobulin heavy constant alpha 1 Homo sapiens 67-71 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 41-45 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 immunoglobulin heavy constant alpha 1 Homo sapiens 41-45 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-1 2019 BACKGROUND: Aberrant galactose-deficient IgA1 molecules (Gd-IgA1) are important causal factors in IgA nephropathy (IgAN); however, the detection of Gd-IgA1 in IgAN is complicated and instable. Gadolinium 148-150 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-2 2019 A monoclonal antibody, KM55, which specifically recognizes Gd-IgA1 has been developed. Gadolinium 59-61 immunoglobulin heavy constant alpha 1 Homo sapiens 62-66 31574506-3 2019 In the present study, we further explored the clinical significance of Gd-IgA1 using KM55. Gadolinium 71-73 immunoglobulin heavy constant alpha 1 Homo sapiens 74-78 31574506-4 2019 METHODS: In this study, we enrolled 75 patients with IgAN and 80 healthy controls and detected the plasma Gd-IgA1 levels using the KM55 ELISA method. Gadolinium 106-108 immunoglobulin heavy constant alpha 1 Homo sapiens 109-113 31574506-5 2019 We also stained -mesangial Gd-IgA1 deposition using KM55. Gadolinium 27-29 immunoglobulin heavy constant alpha 1 Homo sapiens 30-34 31574506-6 2019 RESULTS: We observed that the levels of plasma Gd-IgA1 in IgAN patients were elevated compared to the corresponding levels of healthy controls. Gadolinium 47-49 immunoglobulin heavy constant alpha 1 Homo sapiens 50-54 31574506-7 2019 Patients were divided into 2 groups based on the median of Gd-IgA1. Gadolinium 59-61 immunoglobulin heavy constant alpha 1 Homo sapiens 62-66 31574506-8 2019 Patients with high Gd-IgA1 levels had significantly higher levels of uric acid (UA) and IgA. Gadolinium 19-21 immunoglobulin heavy constant alpha 1 Homo sapiens 22-26 31574506-10 2019 In addition, positive correlations were observed between Gd-IgA1 and Bb, C3a, C4d and MAC. Gadolinium 57-59 immunoglobulin heavy constant alpha 1 Homo sapiens 60-64 31574506-11 2019 Mesangial Gd-IgA1 was positive in IgAN but negative in the normal renal tissue adjacent to neoplasm. Gadolinium 10-12 immunoglobulin heavy constant alpha 1 Homo sapiens 13-17 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 48-50 immunoglobulin heavy constant alpha 1 Homo sapiens 51-55 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 48-50 immunoglobulin heavy constant alpha 1 Homo sapiens 73-77 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 70-72 immunoglobulin heavy constant alpha 1 Homo sapiens 51-55 31574506-12 2019 We next analyzed the correlation between plasma Gd-IgA1 and mesangial Gd-IgA1 deposition. Gadolinium 70-72 immunoglobulin heavy constant alpha 1 Homo sapiens 73-77 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 47-49 immunoglobulin heavy constant alpha 1 Homo sapiens 50-54 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 47-49 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 98-100 immunoglobulin heavy constant alpha 1 Homo sapiens 50-54 31574506-13 2019 The results showed that a high level of plasma Gd-IgA1 was related to the deposition of mesangial Gd-IgA1, although the difference was not significant. Gadolinium 98-100 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31574506-14 2019 CONCLUSION: We verified the elevated level of plasma and -mesangial Gd-IgA1 in patients with IgAN by KM55, which provided an alternative, easy, and reliable tool for diagnosis and activity assessment of IgAN. Gadolinium 68-70 immunoglobulin heavy constant alpha 1 Homo sapiens 71-75 31574506-15 2019 The level of plasma Gd-IgA1 positively correlated with levels of UA, total IgA levels, and complement activation products. Gadolinium 20-22 immunoglobulin heavy constant alpha 1 Homo sapiens 23-27 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 101-105 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114 31844808-1 2019 Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Gadolinium 107-109 immunoglobulin heavy constant alpha 1 Homo sapiens 110-114