PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6628889-5 1983 The antagonistic efficacy of these antidotes against pinacolyl methylphosphonofluoridate may be attributed to their direct antagonism at nicotinic receptor as well as reactivation of inhibited acetylcholinesterase. Soman 53-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. Soman 68-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. Soman 68-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 5080267-0 1972 [Restoration of acetylcholinesterase activity in animals intoxicated with pinacolyl-methylphosphonofluoridate]. Soman 74-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 7426043-0 1980 Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes. Soman 50-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 7426043-0 1980 Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes. Soman 100-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 4586721-0 1973 [Phosphonyloxime of soman; formation and reaction with acetylcholinesterase in vitro]. Soman 20-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 33831382-5 2021 Addition of soman 7.5 nmol/l induced gradual AChE inhibition that became almost complete after 20 min. Soman 12-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 33831382-0 2021 Effects of memantine and its metabolite Mrz 2/373 on soman-induced inhibition of acetylcholinesterase in vitro. Soman 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 33831382-8 2021 It was concluded that it is possible that memantine and Mrz 2/373 can prevent AChE from inhibition by soman, which could, along with known memantine"s neuroprotective activity, explain its potent antidotal effect in soman poisoning. Soman 102-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 33831382-9 2021 The potential effect on aging of the soman-AChE complex warrants further studies. Soman 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 33538594-8 2021 To identify the structural underpinnings of this phenomenon, the structures of tabun, sarin, and soman-inhibited hAChE in complex with HI-6 were determined. Soman 97-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 22768972-3 2012 AChE is a target of several toxins such as insecticide carbofuran, nerve agents, sarin, soman, tabun and VX. Soman 88-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 20192902-4 2010 In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency. Soman 31-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Soman 302-307 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Soman 61-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Soman 61-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Soman 302-307 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Soman 302-307 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 8836126-1 1996 We have examined the effects of 11 substitutions of active centre gorge residues of human acetylcholinesterase (HuAChE) on the rates of phosphonylation by 1,2,2-trimethylpropyl methyl-phosphonofluoridate (soman) and the aging of the resulting conjugates. Soman 155-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 11303072-7 2001 The reactivation time of HI-6 on soman-inhibited AChE was 6 +/- 2 min. Soman 33-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 7619798-1 1995 Molecular mechanics and dynamics combined with semiempirical calculations were carried out for purposes of comparison of the active site characteristics of AChE, trypsin, and chymotrypsin as probed by their diastereomeric adducts with 2-(3,3-dimethylbutyl) methylphosphonofluoridate (soman), methylphosphonate monoester anions, and tetravalent carbonyl intermediates of the reactions of the natural substrates in each case. Soman 284-289 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 8326086-2 1993 Most studies have evaluated effects of the OP nerve agent soman (pinacolyl methylphosphonofluoridate), an irreversible inhibitor of acetylcholinesterase. Soman 65-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152