PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20625233-7	2010	In these assays, D-limonene decreased the expression of TNF-alpha, IL-1beta, and IL-6 in a dose-dependent manner.	Limonene	17-27	interleukin 1 beta	Mus musculus	67-75	
27888114-0	2017	Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 beta and protein expression in spinal cord of mice.	Limonene	0-8	interleukin 1 beta	Mus musculus	78-87	
27888114-8	2017	Limonene also inhibited TNF-alpha and IL-1beta-induced mechanical hyperalgesia.	Limonene	0-8	interleukin 1 beta	Mus musculus	38-46	
27888114-9	2017	Western blot assay demonstrated limonene was capable of increasing SOD expression in the cytoplasm of cells from spinal cord at 4h after intrathecal IL-1beta injection.	Limonene	32-40	interleukin 1 beta	Mus musculus	149-157	
27888114-10	2017	SIGNIFICANCE: These results demonstrate that gp120 causes mechanical hyperalgesia and a peripheral increase in IL-1beta and IL-10, and that prior administration of limonene inhibits these changes.	Limonene	164-172	interleukin 1 beta	Mus musculus	111-119	
27888114-11	2017	Also limonene modulates the activation of SOD expression in the spinal cord after spinal IL-1beta application.	Limonene	5-13	interleukin 1 beta	Mus musculus	89-97	
27888114-12	2017	The ability of limonene to inhibit the mechanical hyperalgesia induced by gp120, TNF-alpha and IL-1beta emphasizes the anti-inflammatory action of limonene, specifically its ability to inhibit cytokine production and its consequences.	Limonene	15-23	interleukin 1 beta	Mus musculus	95-103	
27888114-12	2017	The ability of limonene to inhibit the mechanical hyperalgesia induced by gp120, TNF-alpha and IL-1beta emphasizes the anti-inflammatory action of limonene, specifically its ability to inhibit cytokine production and its consequences.	Limonene	147-155	interleukin 1 beta	Mus musculus	95-103	
23180366-5	2013	In addition, pretreatment with limonene inhibited inflammatory cells and proinflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in BALF.	Limonene	31-39	interleukin 1 beta	Mus musculus	138-155