PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21470398-7	2011	High extracellular potassium and 10 mM tolbutamide abrogated the inhibition of insulin secretion by GA. Glyceraldehyde, dihydroxyacetone, methylpyruvate, GLP-1, and forskolin, an activator of adenylate cyclase, did not abrogate the inhibition.	Glyceraldehyde	104-118	insulin	Homo sapiens	79-86	
14675555-5	2004	If glucose metabolism through the glycolytic pathway is impaired, as in insulin resistance, there will be a build-up of glyceraldehyde, glyceraldehyde-3-phosphate and dihydroxyacetone phosphate with further metabolism to methylglyoxal, a highly reactive ketoaldehyde.	Glyceraldehyde	120-134	insulin	Homo sapiens	72-79	
9972287-2	1998	Glucose, mannose, fructose, glyceraldehyde and dihydroxyacetone all at 8 mM, significantly enhanced the release of insulin elicited by basal concentrations of these carbohydrates (2 mM).	Glyceraldehyde	28-42	insulin	Homo sapiens	115-122	
9224548-3	1997	Two K(+)-ATP channel openers (diazoxide and BPDZ44) inhibited; while a K(+)-ATP channel blocker (tolbutamide) and metabolizable sugars (glucose, glyceraldehyde) significantly stimulated the output of insulin.	Glyceraldehyde	145-159	insulin	Homo sapiens	200-207	
7646447-0	1995	The stimulation of insulin secretion by D-glyceraldehyde correlates with its rate of oxidation in islet cells.	Glyceraldehyde	40-56	insulin	Homo sapiens	19-26	
7646447-1	1995	D-Glyceraldehyde"s capacity to mimic the effect of D-glucose on insulin secretion has not yet been sufficiently substantiated.	Glyceraldehyde	0-16	insulin	Homo sapiens	64-71	
7646447-7	1995	The ratio of the maximum insulin responses D-glyceraldehyde and D-glucose (57%) correlated with the ratio of their respective maximum rates of oxidation (68%).	Glyceraldehyde	43-59	insulin	Homo sapiens	25-32	
7646447-10	1995	The lower potency of D-glyceraldehyde as an insulin secretagogue than D-glucose is determined by the lower capacity of islets to oxidize the triose compared with the hexose.	Glyceraldehyde	21-37	insulin	Homo sapiens	44-51	
8412503-3	1993	However, glyceraldehyde highly attenuated the insulin-secretory response of pancreatic islets to alpha-D-glucose compared with that to beta-D-glucose.	Glyceraldehyde	9-23	insulin	Homo sapiens	46-53	
1596516-7	1992	The carbohydrate insulin secretagogues mannose and D-glyceraldehyde have also been found to induce islet PGE2 release, but the non-secretagogue carbohydrates L-glucose and lactate do not.	Glyceraldehyde	51-67	insulin	Homo sapiens	17-24	
1347743-1	1992	This study examines the effects of donor age on exogenous somatostatin inhibition of insulin secretion stimulated by 10 mM D-glyceraldehyde and by 20 mM beta-D-glucose in isolated perfused rat pancreas.	Glyceraldehyde	123-139	insulin	Homo sapiens	85-92	
1347743-2	1992	Both 6 and 30 nM synthetic somatostatin-14 affect both glyceraldehyde- and glucose-stimulated insulin secretion to a greater degree in pancreases from old animals (24-27 months) than in those from young (2-5 months).	Glyceraldehyde	55-69	insulin	Homo sapiens	94-101	
2245873-6	1990	Because glyceraldehyde, which enters metabolism at the triose phosphates in the glycolytic pathway, is a potent insulin secretagogue but pyruvate, which is metabolized in the mitochondrion, is not an insulin secretagogue, the proximal signal for glucose-induced insulin release originates with an interaction between the central part of the glycolytic pathway and mitochondrial metabolism.	Glyceraldehyde	8-22	insulin	Homo sapiens	112-119	
2186702-7	1990	The effects of glyceraldehyde suggest that glucose signals the first phase of insulin release by an agonist-like mechanism that originates in the cytosol and requires minimal energy.	Glyceraldehyde	15-29	insulin	Homo sapiens	78-85	
2699445-8	1989	Exposing the cells to 1 mM or 2 mM butyrate for two days, resulted in a 50% increase in cellular insulin content at the expense of a partial (1 mM) or complete (2 mM) loss of stimulated insulin release in response to glyceraldehyde or serine.	Glyceraldehyde	217-231	insulin	Homo sapiens	186-193	
2539042-2	1989	Glyceraldehyde has been known to be an insulin secretagogue for more than 15 years.	Glyceraldehyde	0-14	insulin	Homo sapiens	39-46	
2539042-7	1989	These data suggest that besides stimulating insulin release in islets via its entering metabolism by phosphorylation to glyceraldehyde phosphate in the triokinase reaction, glyceraldehyde could be phosphorylated by Pi in the glyceraldehyde phosphate dehydrogenase reaction to form glycerate 1-phosphate which is probably unmetabolizable in islets.	Glyceraldehyde	120-134	insulin	Homo sapiens	44-51	
2452099-0	1988	Single-channel Ba2+ currents in insulin-secreting cells are activated by glyceraldehyde stimulation.	Glyceraldehyde	73-87	insulin	Homo sapiens	32-39	
2452099-4	1988	Glyceraldehyde, a substance evoking insulin secretion from the RINm5F cells, enhances the voltage-activated Ca2+ channel opening by increasing the mean open time and decreasing the longer of the two mean shut times and also decreases the voltage threshold for channel opening.	Glyceraldehyde	0-14	insulin	Homo sapiens	36-43	
2830753-3	1987	Glyceraldehyde stimulated insulin release in a concentration dependent manner, maximum stimulation occurring at 20 mmol/l.	Glyceraldehyde	0-14	insulin	Homo sapiens	26-33	
25582325-1	2015	BACKGROUND: We have previously shown that serum levels of glyceraldehyde-derived advanced glycation end products (Gly-AGEs) are elevated under oxidative stress and/or diabetic conditions and associated with insulin resistance, endothelial dysfunction and vascular inflammation in humans.	Glyceraldehyde	58-72	insulin	Homo sapiens	207-214