PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16533780-7	2006	We next examined MDR1 levels in normal and malignant PBMCs obtained from 15 patients enrolled in clinical trials with depsipeptide and detected up to a 6-fold increase in normal PBMCs and up to an 8-fold increase in circulating tumor cells after depsipeptide administration.	Depsipeptides	118-130	ATP binding cassette subfamily B member 1	Homo sapiens	17-21	
16260035-4	2006	P-gp expression returned to the parental cell level when resistant cells were cultured in depsipeptide-free medium, while resistant cells cultured in the medium containing 16 nM depsipeptide still showed hyper-acetylation of histones.	Depsipeptides	90-102	ATP binding cassette subfamily B member 1	Homo sapiens	0-4	
16260035-8	2006	Among the 28 genes that were upregulated, 15 genes also showed an increased expression in parental cells treated with 4 nM depsipeptide for 48 h, while the other 13 genes including P-gp were different.	Depsipeptides	123-135	ATP binding cassette subfamily B member 1	Homo sapiens	181-185	
16260035-10	2006	These findings suggest that continuous exposure to depsipeptide reversibly induces P-gp, which contributes to the onset of resistance, but the altered gene expression profile of resistant cells may also play a role.	Depsipeptides	51-63	ATP binding cassette subfamily B member 1	Homo sapiens	83-87	
16533780-0	2006	Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).	Depsipeptides	118-130	ATP binding cassette subfamily B member 1	Homo sapiens	10-14	
16533780-2	2006	Because depsipeptide (FR901228, FK228, NSC630176) is a substrate for Pgp, up-regulation of the gene that encodes it, MDR1, would mean that depsipeptide induces its own mechanism of resistance.	Depsipeptides	8-20	ATP binding cassette subfamily B member 1	Homo sapiens	69-72	
16533780-2	2006	Because depsipeptide (FR901228, FK228, NSC630176) is a substrate for Pgp, up-regulation of the gene that encodes it, MDR1, would mean that depsipeptide induces its own mechanism of resistance.	Depsipeptides	8-20	ATP binding cassette subfamily B member 1	Homo sapiens	117-121	
16533780-7	2006	We next examined MDR1 levels in normal and malignant PBMCs obtained from 15 patients enrolled in clinical trials with depsipeptide and detected up to a 6-fold increase in normal PBMCs and up to an 8-fold increase in circulating tumor cells after depsipeptide administration.	Depsipeptides	246-258	ATP binding cassette subfamily B member 1	Homo sapiens	17-21	
16533780-9	2006	These studies suggest that depsipeptide induces its own mechanism of resistance and thus provide a basis for clinical trials evaluating depsipeptide in combination with a Pgp inhibitor.	Depsipeptides	27-39	ATP binding cassette subfamily B member 1	Homo sapiens	171-174	
16223781-0	2006	Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells.	Depsipeptides	95-107	ATP binding cassette subfamily B member 1	Homo sapiens	17-21	
16223781-3	2006	The combination of ATRA and the novel histone deacetylase inhibitor (HDACI) depsipeptide (FK228) induced P-gp expression and prevented growth inhibition and apoptosis in NB4 APL cells subsequently exposed to doxorubicin (DOX).	Depsipeptides	76-88	ATP binding cassette subfamily B member 1	Homo sapiens	105-109	
14996704-8	2004	However, cells selected for resistance to depsipeptide in the presence of a Pgp inhibitor had a Pgp-independent mechanism of resistance.	Depsipeptides	42-54	ATP binding cassette subfamily B member 1	Homo sapiens	76-79	
14996704-8	2004	However, cells selected for resistance to depsipeptide in the presence of a Pgp inhibitor had a Pgp-independent mechanism of resistance.	Depsipeptides	42-54	ATP binding cassette subfamily B member 1	Homo sapiens	96-99	
8980113-0	1996	Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins.	Depsipeptides	30-49	ATP binding cassette subfamily B member 1	Homo sapiens	92-96	
8980113-4	1996	The human MDR1/Pgp conferred about 4-fold resistance to aureobasidin A, a cyclic depsipeptide antifungal antibiotic, on the drug-sensitive yeast strains.	Depsipeptides	81-93	ATP binding cassette subfamily B member 1	Homo sapiens	10-14	
8980113-4	1996	The human MDR1/Pgp conferred about 4-fold resistance to aureobasidin A, a cyclic depsipeptide antifungal antibiotic, on the drug-sensitive yeast strains.	Depsipeptides	81-93	ATP binding cassette subfamily B member 1	Homo sapiens	15-18	
18234154-6	2008	Additionally, 1 microM completely reversed Pgp-mediated resistance to vinblastine, paclitaxel and depsipeptide in SW620 Ad20 cells.	Depsipeptides	98-110	ATP binding cassette subfamily B member 1	Homo sapiens	43-46