PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27509880-0	2016	Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.	Depsipeptides	49-61	H3 histone pseudogene 16	Homo sapiens	139-142	
19233470-5	2009	It is shown that depsipeptide is effective at submicromolar concentrations and acts mainly by apoptosis induction, upregulation of p21 and cell cycle inhibition in G2/M.	Depsipeptides	17-29	H3 histone pseudogene 16	Homo sapiens	131-134	
17644301-0	2008	Romidepsin (depsipeptide) induced cell cycle arrest, apoptosis and histone hyperacetylation in lung carcinoma cells (A549) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression.	Depsipeptides	12-24	H3 histone pseudogene 16	Homo sapiens	155-158	
14996704-4	2004	Treatment with depsipeptide, as well as other histone deacetylase inhibitors, caused induction of histone acetylation, induction of p21 expression, and substantial apoptosis without significant cell cycle arrest.	Depsipeptides	15-27	H3 histone pseudogene 16	Homo sapiens	132-135	
12773551-9	2003	Depsipeptide induced p21(Cip1) expression was reconstituted when cells were pretreated with 5-aza-2"-deoxycytidine.	Depsipeptides	0-12	H3 histone pseudogene 16	Homo sapiens	21-24	
22112863-8	2012	Our results demonstrate that depsipeptide plays an anti-neoplastic role by generating ROS to elicit p53/p21 pathway activation.	Depsipeptides	29-41	H3 histone pseudogene 16	Homo sapiens	104-107	
12481415-2	2002	Here we show that the HDIs sodium butyrate (Bu), trichostatin A (TSA) and depsipeptide (FR901228) all induced p21, but only TSA and FR901228 caused mitotic arrest (in addition to arrest in G1 and G2).	Depsipeptides	74-86	H3 histone pseudogene 16	Homo sapiens	110-113