PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14528273-9	2003	Histone deacetylases (HDACs) can be inhibited by numerous compounds (sodium phenylbutyrate, valproic acid, novel compounds such as depsipeptide), which have entered the clinical arena in similar indications as Dnmt inhibitors.	Depsipeptides	131-143	DNA methyltransferase 1	Homo sapiens	210-214	
18332107-3	2008	Although expression of DNA methyltransferase 1 (DNMT1) was not affected by depsipeptide, a decrease in binding of DNMT1 to the promoter of these genes played a dominant role in depsipeptide-induced demethylation and reactivation.	Depsipeptides	177-189	DNA methyltransferase 1	Homo sapiens	23-46	
18332107-3	2008	Although expression of DNA methyltransferase 1 (DNMT1) was not affected by depsipeptide, a decrease in binding of DNMT1 to the promoter of these genes played a dominant role in depsipeptide-induced demethylation and reactivation.	Depsipeptides	177-189	DNA methyltransferase 1	Homo sapiens	114-119	
18332107-5	2008	Furthermore, both loading of heterochromatin-associated protein 1 (HP1alpha and HP1beta) to methylated H3K9 and binding of DNMT1 to these genes" promoter were significantly reduced in depsipeptide-treated cells.	Depsipeptides	184-196	DNA methyltransferase 1	Homo sapiens	123-128	
15735013-6	2005	Furthermore, RUNX1/MTG8 and DNMT1 were concurrently released from the IL-3 promoter by exposure to depsipeptide or stabilized on the promoter by decitabine treatment.	Depsipeptides	99-111	DNA methyltransferase 1	Homo sapiens	28-33	
12592335-6	2003	Notably, the activity of depsipeptide was enhanced by 5-aza-2"-deoxycytidine, a DNA methyltransferase inhibitor (DNMT).	Depsipeptides	25-37	DNA methyltransferase 1	Homo sapiens	80-111	
12592335-6	2003	Notably, the activity of depsipeptide was enhanced by 5-aza-2"-deoxycytidine, a DNA methyltransferase inhibitor (DNMT).	Depsipeptides	25-37	DNA methyltransferase 1	Homo sapiens	113-117