PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30324757-10 2019 Histopathology examinations showed the ranking of irritations (from slight to severe) were PHT-loaded rh-insulin, negative air control and PS-loaded rh-insulin. Rhodium 102-104 insulin Homo sapiens 105-112 16715386-7 2006 The difference in degradation rate between the insulin-dextran and insulin-trehalose systems observed at 12% RH was eliminated at 43% RH. Rhodium 109-111 insulin Homo sapiens 47-54 16715386-7 2006 The difference in degradation rate between the insulin-dextran and insulin-trehalose systems observed at 12% RH was eliminated at 43% RH. Rhodium 109-111 insulin Homo sapiens 67-74 16715386-7 2006 The difference in degradation rate between the insulin-dextran and insulin-trehalose systems observed at 12% RH was eliminated at 43% RH. Rhodium 134-136 insulin Homo sapiens 47-54 16715386-7 2006 The difference in degradation rate between the insulin-dextran and insulin-trehalose systems observed at 12% RH was eliminated at 43% RH. Rhodium 134-136 insulin Homo sapiens 67-74 16715386-8 2006 In addition, the T1rho of the insulin carbonyl carbon at low humidity (12% RH) was prolonged by the addition of trehalose, but not by the addition of dextran. Rhodium 75-77 insulin Homo sapiens 30-37 16078146-6 2005 The temperature- and Tg-dependence of the degradation rate indicated that the reactivity of insulin in the trehalose formulation is affected by molecular mobility at low humidity (12% RH), such that the ratio of the observed rate constant (k") to the rate constant governed only by the activational barrier (k) was 0.051 at the Tg. Rhodium 184-186 insulin Homo sapiens 92-99 30324757-11 2019 CONCLUSIONS: Both PS- and PHT-loaded rh-insulin dry powders were able to deliver rh-insulin systemically with appropriate pharmacokinetic, pharmacodynamic and safety profiles. Rhodium 37-39 insulin Homo sapiens 40-47