PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12592382-0	2003	ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.	saikosaponin D	115-129	mitogen-activated protein kinase 1	Homo sapiens	0-3	
12592382-3	2003	During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2.0-fold induced by TPA and Saikosaponin a, respectively, whereas that of another transcriptional factor, c-jun, was induced by TPA only.	saikosaponin D	149-163	mitogen-activated protein kinase 1	Homo sapiens	88-92	
33421903-0	2021	Saikosaponin a contributed to CCIN treatment by promoting neutrophil bactericidal activity via activation CBL-dependent ERK pathway.	saikosaponin D	0-14	mitogen-activated protein kinase 1	Homo sapiens	120-123	
32822868-0	2020	Saikosaponin d contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway.	saikosaponin D	0-14	mitogen-activated protein kinase 1	Homo sapiens	147-150	
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	saikosaponin D	117-131	mitogen-activated protein kinase 1	Homo sapiens	90-93	
28990046-13	2017	However, saikosaponin inhibited the HUVEC injury induced by ox-LDL through inhibiting the ERK1/2 and p38 MAPK signaling pathways, and possibly also through the JNK and p38 MAPK signaling pathway.	saikosaponin D	9-21	mitogen-activated protein kinase 1	Homo sapiens	101-104	
28990046-13	2017	However, saikosaponin inhibited the HUVEC injury induced by ox-LDL through inhibiting the ERK1/2 and p38 MAPK signaling pathways, and possibly also through the JNK and p38 MAPK signaling pathway.	saikosaponin D	9-21	mitogen-activated protein kinase 1	Homo sapiens	168-171