PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12592382-0	2003	ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.	saikosaponin D	115-129	cyclin dependent kinase inhibitor 2A	Homo sapiens	46-54	
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	saikosaponin D	117-131	cyclin dependent kinase inhibitor 2A	Homo sapiens	248-251	
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	saikosaponin D	117-131	cyclin dependent kinase inhibitor 2A	Homo sapiens	252-257	
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	saikosaponin D	209-223	cyclin dependent kinase inhibitor 2A	Homo sapiens	61-66	
11444823-6	2001	The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway.	saikosaponin D	30-44	cyclin dependent kinase inhibitor 2A	Homo sapiens	110-115	
11444823-0	2001	Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.	saikosaponin D	62-76	cyclin dependent kinase inhibitor 2A	Homo sapiens	31-35	
11444823-0	2001	Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.	saikosaponin D	62-76	cyclin dependent kinase inhibitor 2A	Homo sapiens	36-41	
11444823-2	2001	Both mRNA and protein of the CDK inhibitor p-16(INK4a) and p-15(INK4b) in HepG2 were greatly induced by saikosaponin a while that of p-21(CIP), p-27(KIP) and other cell cycle related genes were not.	saikosaponin D	104-118	cyclin dependent kinase inhibitor 2A	Homo sapiens	43-47	
11444823-2	2001	Both mRNA and protein of the CDK inhibitor p-16(INK4a) and p-15(INK4b) in HepG2 were greatly induced by saikosaponin a while that of p-21(CIP), p-27(KIP) and other cell cycle related genes were not.	saikosaponin D	104-118	cyclin dependent kinase inhibitor 2A	Homo sapiens	48-53