PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15885361-1	2005	BACKGROUND/AIMS: Ursodeoxycholic acid (UDCA) and its taurine-conjugated derivative, TUDCA, modulate cell death and cell cycle regulators, such as E2F-1 and p53.	ursodoxicoltaurine	84-89	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	156-159	
15255934-0	2004	Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells.	ursodoxicoltaurine	43-68	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	24-27	
15255934-8	2004	Notably, TUDCA modulated Abeta-induced apoptosis, E2F-1 induction, p53 stabilization and Bax expression.	ursodoxicoltaurine	9-14	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	67-70	
15255934-10	2004	In conclusion, the results demonstrate that Abeta-induced apoptosis of PC12 cells proceeds through an E2F-1/p53/Bax pathway, which, in turn, can be specifically inhibited by TUDCA, thus underscoring its potential therapeutic use.	ursodoxicoltaurine	174-179	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	108-111	
15222754-1	2004	We have recently shown that both ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA) prevent transforming growth factor beta1 (TGF-beta1)-induced hepatocyte apoptosis by modulating the E2F-1/p53/Bax pathway.	ursodoxicoltaurine	65-90	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	205-208	
15222754-1	2004	We have recently shown that both ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA) prevent transforming growth factor beta1 (TGF-beta1)-induced hepatocyte apoptosis by modulating the E2F-1/p53/Bax pathway.	ursodoxicoltaurine	92-97	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	205-208	
30998645-13	2020	TUDCA upregulated SIRT1-FXR activity, which inhibited expression and acetylation of NF-kappaB and p53 and increased FoxM1 expression, leading to decreased inflammatory response and apoptosis and increased proliferative capacity in hepatocytes, and attenuation of liver injury.	ursodoxicoltaurine	0-5	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	98-101	
31152635-6	2019	While GCDC upregulated the expression of several pro-inflammatory genes, co-perfusion with TUDC increased the expression of pro-proliferative and anti-apoptotic p53 target genes.	ursodoxicoltaurine	91-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	161-164	
31152635-7	2019	In line with this, levels of serine20-phosphorylated p53 and of its target gene p21 were elevated by GCDC in a TUDC-sensitive way.	ursodoxicoltaurine	111-115	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	53-56