PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33321116-7	2021	The Stz mice that received 300 mg/kg TUDCA during 10 days (Stz+TUDCA), showed improvement in glucose tolerance and insulin sensitivity, reduced fasted and fed glycemia, increased islet mass and beta-cell area, as well as increased glucose-stimulated insulin secretion, compared with Stz mice that received only PBS.	ursodoxicoltaurine	37-42	insulin	Homo sapiens	115-122	
33321116-7	2021	The Stz mice that received 300 mg/kg TUDCA during 10 days (Stz+TUDCA), showed improvement in glucose tolerance and insulin sensitivity, reduced fasted and fed glycemia, increased islet mass and beta-cell area, as well as increased glucose-stimulated insulin secretion, compared with Stz mice that received only PBS.	ursodoxicoltaurine	37-42	insulin	Homo sapiens	250-257	
33321116-7	2021	The Stz mice that received 300 mg/kg TUDCA during 10 days (Stz+TUDCA), showed improvement in glucose tolerance and insulin sensitivity, reduced fasted and fed glycemia, increased islet mass and beta-cell area, as well as increased glucose-stimulated insulin secretion, compared with Stz mice that received only PBS.	ursodoxicoltaurine	63-68	insulin	Homo sapiens	115-122	
33321116-7	2021	The Stz mice that received 300 mg/kg TUDCA during 10 days (Stz+TUDCA), showed improvement in glucose tolerance and insulin sensitivity, reduced fasted and fed glycemia, increased islet mass and beta-cell area, as well as increased glucose-stimulated insulin secretion, compared with Stz mice that received only PBS.	ursodoxicoltaurine	63-68	insulin	Homo sapiens	250-257	
20522594-2	2010	Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes to insulin resistance, and treatment with tauroursodeoxycholic acid (TUDCA), a bile acid derivative that acts as a chemical chaperone to enhance protein folding and ameliorate ER stress, increases insulin sensitivity.	ursodoxicoltaurine	139-164	insulin	Homo sapiens	100-107	
31508171-3	2019	In our study, 3T3-L1 adipocytes were pre-treated with ERS inhibitors tauroursodeoxycholic acid (TUDCA), Ex-4 and an ERS inducer tunicamycin (TM) then induced insulin resistance.	ursodoxicoltaurine	69-94	insulin	Homo sapiens	158-165	
30416448-8	2018	In ex vivo experiments, the incubation of aortic rings with resistin impaired insulin- but not acetylcholine-induced vasodilation, which was restored by TUDCA.	ursodoxicoltaurine	153-158	insulin	Homo sapiens	78-85	
22374970-9	2012	Attenuation of ER stress using chemical chaperones (trimethylamine N-oxide or tauroursodeoxycholic acid) partially protected against the lipid-induced changes in insulin signaling.	ursodoxicoltaurine	78-103	insulin	Homo sapiens	162-169	
20522594-7	2010	In addition, therapy with TUDCA, but not placebo, increased muscle insulin signaling (phosphorylated insulin receptor substrate(Tyr) and Akt(Ser473) levels) (P < 0.05).	ursodoxicoltaurine	26-31	insulin	Homo sapiens	67-74	
20522594-3	2010	The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women.	ursodoxicoltaurine	57-62	insulin	Homo sapiens	85-92	
20522594-3	2010	The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women.	ursodoxicoltaurine	57-62	insulin	Homo sapiens	138-145	
20165829-6	2010	Interestingly, pretreatment of both rat and human myotubes with the chemical chaperones 4-phenylbutyric acid (PBA) or tauroursodeoxycholic acid (TUDCA), completely prevented the effect of glucosamine on both ER stress induction and insulin-induced glucose uptake.	ursodoxicoltaurine	118-143	insulin	Homo sapiens	232-239	
20165829-6	2010	Interestingly, pretreatment of both rat and human myotubes with the chemical chaperones 4-phenylbutyric acid (PBA) or tauroursodeoxycholic acid (TUDCA), completely prevented the effect of glucosamine on both ER stress induction and insulin-induced glucose uptake.	ursodoxicoltaurine	145-150	insulin	Homo sapiens	232-239