PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28729823-10	2017	However, the administration of the Akt inhibitor MK2206 or siRNA targeting of Akt abolished the beneficial effects of TUDCA.	ursodoxicoltaurine	118-123	thymoma viral proto-oncogene 1	Mus musculus	35-38	
31254957-7	2019	In addition, TUDCA increased the expression of phospho-Akt (p-Akt).	ursodoxicoltaurine	13-18	thymoma viral proto-oncogene 1	Mus musculus	55-58	
31254957-7	2019	In addition, TUDCA increased the expression of phospho-Akt (p-Akt).	ursodoxicoltaurine	13-18	thymoma viral proto-oncogene 1	Mus musculus	62-65	
31254957-8	2019	Furthermore, we confirmed that TUDCA inhibited the apoptosis of intestinal cells by modulating the PERK-eIF2alpha ERS pathway and the Akt pathway in vitro studies.	ursodoxicoltaurine	31-36	thymoma viral proto-oncogene 1	Mus musculus	134-137	
31254957-9	2019	Besides, TUDCA effects were impaired by AKT specific inhibitor MK2206 in vitro studies.	ursodoxicoltaurine	9-14	thymoma viral proto-oncogene 1	Mus musculus	40-43	
31254957-10	2019	Therefore, these results indicated that TUDCA alleviated intestinal injury in a mouse model of NEC and inhibited ERS-mediated intestinal cell apoptosis by activating the Akt pathway.	ursodoxicoltaurine	40-45	thymoma viral proto-oncogene 1	Mus musculus	170-173	
28729823-0	2017	Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation.	ursodoxicoltaurine	18-43	thymoma viral proto-oncogene 1	Mus musculus	78-81	
28729823-10	2017	However, the administration of the Akt inhibitor MK2206 or siRNA targeting of Akt abolished the beneficial effects of TUDCA.	ursodoxicoltaurine	118-123	thymoma viral proto-oncogene 1	Mus musculus	78-81	
28729823-11	2017	Taken together, our results indicate that TUDCA may attenuate early brain injury via Akt pathway activation.	ursodoxicoltaurine	42-47	thymoma viral proto-oncogene 1	Mus musculus	85-88	
24142192-9	2013	Palmitate-induced phospho-Akt (Ser473) downregulation was also inhibited by TUDCA or SP600125.	ursodoxicoltaurine	76-81	thymoma viral proto-oncogene 1	Mus musculus	26-29	
21542787-6	2011	Treatment with tunicamycin also dephosphorylated Akt and its downstream signal glycogen synthase kinase 3beta (GSK3beta) (leading to activation of GSK3beta), the effect of which was abrogated by Akt activation and TUDCA.	ursodoxicoltaurine	214-219	thymoma viral proto-oncogene 1	Mus musculus	49-52	
22773138-11	2012	We conclude that TUDCA is neuroprotective in an in vivo model of PD, acting mainly by modulation of JNK activity and cellular redox thresholds, together with activation of the Akt pro-survival pathway.	ursodoxicoltaurine	17-22	thymoma viral proto-oncogene 1	Mus musculus	176-179	
21542787-6	2011	Treatment with tunicamycin also dephosphorylated Akt and its downstream signal glycogen synthase kinase 3beta (GSK3beta) (leading to activation of GSK3beta), the effect of which was abrogated by Akt activation and TUDCA.	ursodoxicoltaurine	214-219	thymoma viral proto-oncogene 1	Mus musculus	195-198	
34624320-10	2021	SIGNIFICANCE: We provide novel evidence that TUDCA may be an agonist of the IR, in turn activating AKT and contributing, at least in part, to its beneficial effects upon glucose homeostasis.	ursodoxicoltaurine	45-50	thymoma viral proto-oncogene 1	Mus musculus	99-102	
34274852-6	2021	And it showed that TUDCA activated the Akt/mTOR/S6K signaling pathway and inhibited FoxO3a transcriptional activity to decreased expression of MuRF1 and Atrogin-1, while blocking Akt by MK2206 blocked these effects of TUDCA on myotubes.	ursodoxicoltaurine	218-223	thymoma viral proto-oncogene 1	Mus musculus	39-42	
34274852-6	2021	And it showed that TUDCA activated the Akt/mTOR/S6K signaling pathway and inhibited FoxO3a transcriptional activity to decreased expression of MuRF1 and Atrogin-1, while blocking Akt by MK2206 blocked these effects of TUDCA on myotubes.	ursodoxicoltaurine	218-223	thymoma viral proto-oncogene 1	Mus musculus	179-182